The action of Lipoxin-A on glomerular microcirculatory dynamics in the rat

Abstract

Intrarenal administration of 750 ng/kg/min of LX-A in euvolemic rats resulted in significant increases in single nephron GFR (38.4±1.7 to 45.5±3.0 nl/min) and plasma flow rate (95±6 to 127±9 nl/min). The latter was due to a dramatic fall in afferent arteriolar resistance. Mean transcapillary hydraulic pressure difference increased from 33±1 to 43±3 mmHg (p<0.05) and the glomerular capillary ultrafiltration coefficient fell from 0.060±0.013 to 0.033±0.005 nl/(s·mmHg) (p<0.05). These responses to LXA in the renal microcirculation are in sharp contrast to those previously observed for the leukotrienes, and thus may represent the first example of counterregulatory (constrictor/dilator) vascular interactions within the lipoxygenase pathways.