Biochemical and Biophysical Research Communications
Lipoprotein lipase-catalyzed hydrolysis of phospholipid monolayers: Effect of fatty acyl composition on enzyme activity
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Lipoprotein size is a main determinant for the rate of hydrolysis by exogenous LPL in human plasma
2022, Journal of Lipid ResearchCitation Excerpt :Taking these caveats into account, there were still significant positive and negative correlations between the LPL activity recorded by ITC and the FA composition of the plasma samples (Fig. 1, panels A and B). The preference of LPL for TG that contain unsaturated FAs is well known from previous studies (45–47). There was a weak positive correlation between the activity of LPL in plasma, recorded by ITC, and the level of monounsaturated FAs (Fig. 1, panels A and B).
Differential postprandial incorporation of 20:5n-3 and 22:6n-3 into individual plasma triacylglycerol and phosphatidylcholine molecular species in humans
2020, Biochimica et Biophysica Acta - Molecular and Cell Biology of LipidsCitation Excerpt :In this context, the molecular specificity of enterocyte TG and PC synthesis may be an important factor in the postprandial metabolism of blood lipids. The two principal enzymes that hydrolyse esterified fatty acids in blood; lipoprotein lipase (LPL) and lecithin-cholesterol acyltransferase (LCAT) exhibit differential activity towards TG and PC molecular species, respectively, according to fatty acid chain length, unsaturation and the distribution of fatty acids between sn positions on the glycerol moiety of TG [14,15]. LCAT preferentially hydrolyses sn-1 16:0 PC molecular species when paired with sn-2 polyunsaturated fatty acids (PUFA) including 20:4n-6 or 22:6n-3 [16].
7 Enzymes involved in triglyceride hydrolysis
1987, Bailliere's Clinical Endocrinology and MetabolismActivation of lipoprotein lipase by N-α-palmitoyl (56-79) fragment of apolipoprotein C-II
1986, Biochemical and Biophysical Research CommunicationsHydrolysis of lipid monolayers and the substrate specificity of hepatic lipase
1986, Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism