Research report
Lithium and ion chelators mimicked morphine in the production of explosive motor behavior

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Intraventricular infusions of lithium and ion chelators mimicked morphine in the production of explosive motor behavior (EMB). Naloxone (20 mg/kg) did not antagonize EMB. In vitro calcium assays indicated that only ion chelators directly interacted with calcium. The behavioral and the in vitro results indicate that although ion chelators may induce EMB as a function of their ability to bind ions, this is not the case for morphine and lithium.

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1

We thank Ralph Berman and Brett-Pat Canada Ltd. for their financial support of this research. This research was also supported by grants from FCAC Québec.

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