Biochemical and Biophysical Research Communications
The carcinoembryonic antigen (CEA) contains multiple immunoglobulin-like domains
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Cited by (105)
Possible participation of colloid antigen 2 and abhormone (IgG with hormone activity) for the etiology of Graves’ disease
2019, Medical HypothesesCitation Excerpt :We reported the occurrence of an immunological cross-reaction between CEA (carcinoembryonic antigen; MW = 180,000) and α1-acid glycoprotein (MW = 60,000) [16]. CEA is known as a member of the IgG supergene family [17–19] and the serum CEA concentration in normal subjects is extremely low (5 ng/ml). Based on this example, I speculate that many ancient or ancestral proteins may have been produced as an IgG type and that serum concentrations of these ancestral versions are extremely low (Table 3).
Cleavage of carcinoembryonic antigen induces metastatic potential in colorectal carcinoma
2005, Biochemical and Biophysical Research CommunicationsCitation Excerpt :No other metastasis was found in any mice. CEA, GPI-anchored protein, is a member of cell surface glycoproteins of immunoglobulin superfamily [11] and soluble form of CEA, after cleavage from the cell membrane, is measured in the serum of the patient with cancer as widely used tumor marker. Because CEA is overexpressed in more than 50% of human cancers [12], it would seem experimentally and clinically important to elucidate a mechanism of releasing CEA from the cell surface.
Prognostic significance of circulating antibodies against carcinoembryonic antigen (anti-CEA) in patients with colon cancer
2000, American Journal of GastroenterologyCitation Excerpt :It has a high carbohydrate content (∼40–75%) and contains multiple immunoglobulin domains (2). CEA is a cell adhesion molecule and a member of a large, closely related family of molecules sharing many common epitopes (3, 4). CEA is capable of binding to an 80-Kb Kupffer cell receptor by the peptide sequence PELPK, and stimulates cytokine production.
Epitope mapping of monoclonal antibodies against N-domain of carcinoembryonic antigen
1999, Immunology LettersOligomerization of N-terminal domain of carcinoembryonic antigen (CEA) expressed in Escherichia coli
1998, Biochemical and Biophysical Research Communications