Three novel molecular forms of biliary glycoprotein deduced from cDNA clones from a human leukocyte library*

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Three cDNA clones that encode three novel variants of biliary glycoprotein a (BGPa), a glycoprotein belonging to the CEA gene family, were identified in a human leukocyte cDNA library. The domain structures of the predicted proteins of the three clones W211, W233 and W239 are N-A1-B1-A2, N-A1-B1 and N-A1-B1-C, respectively; they lack the transmembrane and cytoplasmic domains that exist in the four BGP species (BGPa, BGPb, BGPc and BGPd) previously reported. Their sequences from N to B1 or to A2 are virtually identical to those of BGPa-d. Comparison with the genomic sequence for BGPa-d suggested that these three new BGP variants as well as BGPa-d are generated from the same single gene by alternative splicing of RNA.

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In this paper, we use the new nomenclature for the CEA gene family members (Ref. 17). The three cDNA clones in this paper, W211, W233 and W239, will be designated as BGPg, BGPh and BGPi, respectively.

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