Biochemical and Biophysical Research Communications
Receptor-mediated activation of arachidonic acid release in mouse peritoneal macrophages is linked to extracellular calcium influx
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Cited by (18)
Cellular Assays for Evaluating Calcium-Dependent Translocation of cPLA<inf>2</inf>α to Membrane
2017, Methods in EnzymologyCitation Excerpt :cPLA2α is subject to complex mechanisms of regulation that are important for controlling the levels of free arachidonic acid available for metabolism through the cyclooxygenase and lipoxygenase pathways. Initial characterization of cPLA2α showed that it required calcium for activity in vitro consistent with cellular studies showing that calcium-mobilizing agonists induce arachidonic acid release (Clark, Milona, & Knopf, 1990; Fernandez & Balsinde, 1991; Kramer, Roberts, Manetta, & Putnam, 1991; Leslie, Voelker, Channon, Wall, & Zelarney, 1988; Rittenhouse-Simmons & Deykin, 1977; Rzigalinski, Blackmore, & Rosenthal, 1996). Calcium was found to promote the interfacial binding of cPLA2α to phospholipid vesicles in vitro and to cellular membranes (Channon & Leslie, 1990; Clark et al., 1991; Glover et al., 1995; Hirabayashi et al., 1999; Peters-Golden, Song, Marshall, & Brock, 1996; Schievella, Regier, Smith, & Lin, 1995).
Involvement of calcium-independent phospholipase A<inf>2</inf> in hydrogen peroxide-induced accumulation of free fatty acids in human U937 cells
2002, Journal of Biological ChemistryCitation Excerpt :In the next series of experiments, the cells were depleted of their intracellular Ca2+ by treating them with 40 μm quin2/AM plus 1 mm EGTA in a Ca2+-free medium. This procedure buffers and clamps the intracellular calcium concentration at very low levels (about 10−8m) (32). Under these conditions, the AA response to H2O2 remained unchanged, whereas the ConA response was abolished (Fig. 5).
The role of calcium and phosphorylation of cytosolic phospholipase A<inf>2</inf> in regulating arachidonic acid release in macrophages
1998, Journal of Biological ChemistryAlterations of fatty acyl turnover in macrophage glycerolipids induced by stimulation. Evidence for enhanced recycling of arachidonic acid
1997, Biochimica et Biophysica Acta - Lipids and Lipid MetabolismEthanol inhibits zymosan-stimulated eicosanoid production in mouse peritoneal macrophages
1994, Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism