Electroconductivity changes during the mitotic cycle in Ehrlich ascites tumour cells

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Abstract

Ehrlich ascites tumour cells were separated according to their size by a velocity sedimentation technique in a linear stabilizing viscosity gradient. Fractions obtained were found to be considerably enriched in cells in the G1, S and G2 periods. The content of viable cells in all the fractions was not less than 95 %, while that of the non-tumour cells was about 13 %.

It was shown that the specific electroconductivity of the cells was high in the G1 period, decreased by a factor of 2–2.5 in the S period and increased again in the G2 period. Some possible reasons for the observed changes in cell membrane permeability and their role in cell metabolism are discussed.

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