Elsevier

Clinica Chimica Acta

Volume 179, Issue 2, 15 February 1989, Pages 197-200
Clinica Chimica Acta

Short communication
Insulin binding to erythrocytes and fatty acid composition of erythrocyte membrane phospholipids in healthy men

https://doi.org/10.1016/0009-8981(89)90167-8Get rights and content

Abstract

The relationship between specific insulin binding to insulin receptors on erythrocytes and erythrocyte membrane phospholipid fatty acid pattern was evaluated in 11 healthy men. A significant negative correlation between insulin binding and the proportion of w-6 family essential fatty acids, especially linoleic acid (r = -0.82, p < 0.01) and arachidonic acid (r = -0.73, p < 0.05) in erythrocyte membrane was found. On the other hand significant positive correlation between insulin binding and the content of nonessential fatty acids (r = +0.65, p < 0.05) was seen.

Data presented support the hypothesis that the fatty acid composition of membrane phospholipids may modify properties of insulin receptors.

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