Elsevier

Clinica Chimica Acta

Volume 40, Issue 1, August 1972, Pages 115-120
Clinica Chimica Acta

Interference in glucose oxidase-peroxidase blood glucose methods

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Abstract

Interference by certain compounds with the glucose oxidase-peroxidase system used in blood glucose estimations appears to be a function of the oxygen affinity of the oxygen acceptor chromogen or the oxidative coupling system. It has been shown1 that tolazamide interferes seriously with the Boehringer GOD-PERID blood glucose method. By utilising other compounds with similar chemical groups, it was found possibleto identify the group in the tolazamide molecule that caused interference and consequently to predict the effects of other compounds on such blood glucose methods.

A comparison of three chromogenic systems was also performed. These were guaiacum2, phenol-4-aminophenazone3 and the Boehringer 2'2-diazo-di(3-ethyl benzthiazoline-6-sulphonic acid) (ABTS). Some of the advantages and disadvantages of these three systems are discussed.

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There are more references available in the full text version of this article.

Cited by (0)

1

P. Sharp, C. Riley, J. G. H. Cook and P. J. F. Pink, Clin. Chim. Acta, 36 (1972) 93.

2

G. Morley, A. Dawson and V. Marks, Proc. Assoc. Clin. Biochem., 5 (1968) 42.

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