Evolution of tumor cytogenetic aberrations and N-myc oncogene amplification in a case of disseminated neuroblastoma

doi:10.1016/0165-4608(87)90057-4

Cancer Genetics and Cytogenetics

Volume 26, Issue 2, June 1987, Pages 235-244

https://doi.org/10.1016/0165-4608(87)90057-4 Get rights and content

Abstract

Chromosome analyses including in situ hybridization with the protooncogene N-myc were carried out at diagnosis and several times at relapse in the bone marrow cells of a girl with disseminated neuroblastoma (stage IV) at ages 9, 23, 24, and 26 months, respectively. The tumor karyotype was pseudodiploid exhibiting partial monosomy for the short arm of chromosome #1, an aberration of the short arm of chromosome #2, and double minutes at diagnosis. Further structural aberrations of chromosomes #4, #6, and #17, and homogeneously staining regions could be demonstrated at relapse. In particular, the following structural aberrations were encountered: t(1;?)(p22;?),t(2;?)(p24;?), t(4;6)(q31;q25), and a der(17q). All tumor metaphases without homogeneously staining regions contained double minutes. N-myc, normally positioned within bands 2p23–24, was found to be amplified in a homogeneously staining region on the short arm of chromosome #15 by in situ hybridization. It is speculated that the translocation t(2;?)(p24;?) might be related to N-myc oncogene activation and subsequent amplification.

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^☆: This article is part of H. Christiansen's doctoral thesis

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Evolution of tumor cytogenetic aberrations and N-myc oncogene amplification in a case of disseminated neuroblastoma☆

Abstract

Cancer Genet Cytogenet

Lancet

Hum Pathol

Cancer Genet Cytogenet

Specific chromosomal aberrations in human neuroblastoma

Am J Hum Genet

Tumor karyotype may be important in the prognosis of human neuroblastoma

J Cancer Res Clin Oncol

A novel chromosome abnormality in human neuroblastoma and antifolate-resistant Chinese hamster cell lines in culture

J Natl Cancer Inst

Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumor

Nature

Chromosome localization in normal human cells and neuroblastoma of a gene related to c-myc

Nature