Trisomy 8 and an unbalanced t(5;17)(q11;p11) characterize two karyotypically independent clones in a case of idiopathic myelofibrosis evolving to acute nonlymphoid leukemia
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Cited by (7)
Cytogenetic and molecular genetic abnormalities in agnogenic myeloid metaplasia
2005, Seminars in OncologyCitation Excerpt :A third of cases possess an abnormal karyotype at diagnosis, a figure that increases if follow-up studies are undertaken.17,21,22 Evolution to more complex karyotypic patterns may accompany clinical progression,23,24 a finding consistent with the multi-step precess of leukemogenesis. Indeed, cytogenetic abnormalities, typically complex changes, increase to approximately 90% following acute transformation.22
Multiple unrelated clones in myelodysplastic syndrome and in acute myeloid leukemia
1996, Cancer Genetics and CytogeneticsCytogenetic biclonality in malignant hematologic disorders
1992, Cancer Genetics and CytogeneticsCytogenetic and molecular genetic aspects of idiopathic myelofibrosis
2002, Acta Haematologicadic(5;17): A recurring abnormality in malignant myeloid disorders associated with mutations of TP53
1997, Genes Chromosomes and CancerAcute promyelocytic leukaemia (M3): Relapse with acute myeloblastic leukaemia (M2) and dic(5;17) (q11; p11)
1995, American Journal of Hematology
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