Mutation Research/Environmental Mutagenesis and Related Subjects
Chromosomal abnormalities and sister-chromatid exchange in bone marrow cells of mice and Chinese hamsters after inhalation and intraperitoneal administration: I. diepoxybutane
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Cited by (15)
Health risk assessment of 1,3-butadiene as a Priority Substance in Canada
2001, Chemico-Biological InteractionsCitation Excerpt :Butadiene was genotoxic in germ cells of male mice in multiple assays, while negative results were obtained in the single dominant lethal study in rats [50,62–71]. Unlike the observations with the parent compound, however, there is little evidence of species differences in the sensitivity to genotoxic effects in somatic or germ cells induced by the epoxide metabolites of butadiene (EB, DEB and EBD), although there was some indication of interstrain variability [34,36,56,69,72–84]. These data suggest that interspecies differences in sensitivity to butadiene-induced genotoxicity are related to quantitative differences in the formation of active metabolites.
A review of the genetic and related effects of 1,3-butadiene in rodents and humans
2000, Mutation Research - Reviews in Mutation ResearchCitation Excerpt :Dose-related increases in the frequency of SCEs were observed in bone marrow and in alveolar macrophages from both intact and partially hepatectomized mice as well as in the regenerating livers of hepatectomized mice exposed to DEB by i.p. injection [149,150]. SCEs were also induced in NMRI mouse bone-marrow following inhalation exposure to DEB [149]. No SCE data were available for rats treated with DEB.
Evaluation of the rodent micronucleus assay in the screening of IARC carcinogens (Groups 1, 2A and 2B): The summary report of the 6th collaborative study by CSGMT/JEMS · MMS
1997, Mutation Research - Genetic Toxicology and Environmental MutagenesisAnalysis of micronuclei induced by 1,3-butadiene and its metabolites using fluorescence in situ hybridization
1996, Mutation Research - Fundamental and Molecular Mechanisms of MutagenesisSister-chromatid exchange and chromosome aberrations for 4 aliphatic epoxides in mice
1989, Mutation Research/Genetic ToxicologyChromosomal abnormalities and sister-chromatid exchange in bone marrow cells of mice and Chinese hamsters after inhalation and intraperitoneal administration. II. Cyclophosphamide
1988, Mutation Research/Environmental Mutagenesis and Related Subjects