Effect of glycerol and glucose additions on lipogenesis from acetate in rat and cow mammary tissue

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Abstract

  • 1.

    1. Fatty acid synthesis in cow and rat mammary tissue was compared utilizing tissue slice incubations.

  • 2.

    2. Lipogenesis occurred in cow tissue with acetate as the only substrate, but was negligible in rat tissue.

  • 3.

    3. Glucose additions stimulated lipogenesis from acetate 3-fold in cow and 115-fold in rat tissue.

  • 4.

    4. In the presence of glycerol, acetate incorporation into fatty acids represented 63 and 2 per cent of the rate found with glucose additions for cow and rat, respectively.

  • 5.

    5. Species differences noted were consistent with ruminant mammary tissue having alternate means of generating a portion of NADPH from acetate, presumably via NADP-isocitrate dehydrogenase.

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Present address: Pharmacology Department, Shell Development Company, P.O. Box 4248, Modesto, California 95352.

Present address: Director of Nutritional Research, Animal Health Products Division, Smith Kline & French Laboratories, 1600 Paoli Pike, West Chester, Pennsylvania 19380.

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