Elsevier

Gene

Volume 102, Issue 2, 30 June 1991, Pages 261-264
Gene

Short communication
Immunoglobulin heavy-chain joining genes in the rat: comparison with mouse and human

https://doi.org/10.1016/0378-1119(91)90087-RGet rights and content

Abstract

We have cloned by the polymerase chain reaction a 2.1-kb fragment carrying heavy-chain joining (JH) gene segments and a part of the JH-Cμ intron of the rat. Sequencing showed that the rat genome has four functional JH segments and that only a slight divergence has occurred after the separation of rat and mouse. A systematic sequence comparison between the two species and human revealed an additional JH pseudogene in rat and mouse 5′ of JH1 which has not been described so far. The implications in evolutionary terms are discussed. In addition, we give an assessment of the misincorporation rate of the Taq polymerase.

References (20)

There are more references available in the full text version of this article.

Cited by (11)

View all citing articles on Scopus
View full text