Mini reviewSignal transduction pathways involving RAS
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Cited by (63)
Allostery: Allosteric Cancer Drivers and Innovative Allosteric Drugs
2022, Journal of Molecular BiologyCitation Excerpt :Recently, we resolved the tantalizing question of how to understand same gene, and even same mutations, promoting both cancer and neurodevelopmental disorder.157 Wild-type Ras regulates cell growth and division.158–165 It binds multiple effectors and signals through multiple pathways.
Inhibition of Nonfunctional Ras
2021, Cell Chemical BiologyCitation Excerpt :That is, we suggest drug classification based on its mechanism of action as it would help guide its design. Wild-type Ras regulates cell growth and division (Bryant et al., 2014; Cox and Der, 2010; Crespo and Leon, 2000; Drosten et al., 2010; Lu et al., 2016b; Pylayeva-Gupta et al., 2011; Wiesmuller and Wittinghofer, 1994). An activated receptor tyrosine kinase (RTK), such as epidermal growth factor receptor (EGFR) (Moran et al., 1991; Nussinov et al., 2020), recruits the Son of Sevenless (SOS), a Ras-specific guanine nucleotide exchange factor (GEF).
Computational physical organic chemistry using the empirical valence bond approach
2019, Advances in Physical Organic ChemistryCitation Excerpt :As one example, Schweins and co-workers67 performed experiments to study the mechanism of the Ras GTPase catalyzed hydrolysis of GTP to GDP, both in the presence and absence of the GTPase activating protein (GAP).68 These proteins are biologically important as they play a crucial role in signal transduction pathways.69 Using LFER, it is possible to probe the extent to which perturbations in reaction conditions or mutations of key active-site residues can affect the mechanism of a reaction (and the nature of the associated transition states), which can then be verified using computational approaches.
Pseudomonas aeruginosa toxins
2015, The Comprehensive Sourcebook of Bacterial Protein ToxinsMultifaceted role of Rho, Rac, Cdc42 and Ras in intercellular junctions, lessons from toxins
2009, Biochimica et Biophysica Acta - BiomembranesCitation Excerpt :Ras proteins also cycle between a GTP active form and a GDP inactive form regulated by specific GEF and GAP proteins. Activated Ras interacts and activates Raf-kinase, which in turn passes the signal on to MAP kinase pathways and then on transcriptional factors [43,44]. It has emerged that extensive cross-talk exist between Ras and Rho GTPase families [37, 38, 44].
Role of the arginine finger in Ras·RasGAP revealed by QM/MM calculations
2007, FEBS Letters