On the origin of enzymatic species

doi:10.1016/0968-0004(93)90091-Z

Trends in Biochemical Sciences

Volume 18, Issue 10, October 1993, Pages 372-376

https://doi.org/10.1016/0968-0004(93)90091-Z Get rights and content

Abstract

The diversity of enzyme catalytic function is remarkable, particularly when one considers that ancestral life forms must have started with a much smaller ensemble of proteins. In this article, we discuss the evolution of the mandelate pathway in pseudomonads as an example of how catalytic diversity may have evolved. We suggest that existing enzymes that catalyse the chemistry needed to accomplish a transformation were recruited, followed by the evolution of specific binding.

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Trends in Biochemical Sciences

On the origin of enzymatic species

Abstract

Trends Biochem. Sci.

Curr. Opin. Struct. Biol.

Gene

J. Biol. Chem.

Biochemistry

Annu. Rev. Microbiol.

J. Bacteriol.

J. Bacteriol.

J. Bacteriol.