MHC class II invariant chains in antigen processing and presentation

https://doi.org/10.1016/0968-0004(89)90013-3Get rights and content

Abstract

Most protein antigens cannot elicit a T-cell response unless they are processed to peptides, which are then presented to T lymphocytes by surface MHC class II molecules. Recent evidence supports an essential role of the invariant chain associated with class II MHC polypeptides in antigen processing.

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