Journal of Fermentation and Bioengineering
Cloning and nucleotide sequencing of new glutaryl 7-ACA and cephalosporin C acylase genes from Pseudomonas strains
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2018, Journal of Bioscience and BioengineeringCitation Excerpt :GK16 (25), Pseudomonas sp. A14, and P. diminuta N176 (26). The summary of the amino acid sequence alignment between DSA and these enzymes is shown in Table 3.
Determination of the second autoproteolytic cleavage site of cephalosporin C acylase and the effect of deleting its flanking residues in the α-C-terminal region
2014, Journal of BiotechnologyCitation Excerpt :Recently, the CPC acylase has garnered great interest because it can directly convert CPC into 7-ACA; therefore, it possesses great potential for producing cephalosporin antibodies via a simpler process with low cost, although its catalytic performance, including its activity and product inhibition resistance, is not yet as satisfactory as that of the GL-7-ACA acylase (Sonawane, 2006). Some studies focused on identifying more active enzymes from different microbial sources, such as Pseudomonas sp. 130 (Oh et al., 2003; Pollegioni et al., 2005; Zhang et al., 2005) and Pseudomonas diminuta N176 (Aramori et al., 1991; Ishii et al., 1995; Saito et al., 1996). Other scientists engineered the enzyme either rationally or randomly to improve the catalytic specificity toward the substrate CPC by either the CPC acylase or GL-7-ACA acylase (Binder et al., 1994; Oh et al., 2003; Pollegioni et al., 2005; Shin et al., 2005; Wang et al., 2012a).
Cephalosporin Acylase Precursor, Glutaryl-7-aminocephalosporanic Acid Acylase Precursor
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