Monoamines and their metabolites in the amphibian (Ambystoma tigrinum) brain: Quantitative changes during metamorphosis and captivity

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Abstract

  • 1.

    1. Monoamine neurotransmitters (epinephrine, norepinephrine, dopamine, serotonin and some of their metabolites (DOPEG, MHPG, DOPAC, 5-HIAA) were measured by HPLC in extracts from telencephalon (TEL) and diencephalon-midbrain (DM) before, during and at the end of metamorphosis.

  • 2.

    2. During metamorphosis MHPG increased and 5-HIAA decreased in TEL and DM while DOPEG decreased only in DM.

  • 3.

    3. Monoamine levels were greater in the TEL and a larger increase in MHPG occurred there.

  • 4.

    4. Captivity without metamorphosis also caused a significant depression of 5-HIAA in TEL and depression of DOPEG, MHPG and DOPAC in DM.

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  • Cited by (6)

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