Elsevier

Clinical Biochemistry

Volume 8, Issues 1–6, February 1975, Pages 199-205
Clinical Biochemistry

Carbohydrate metabolism in the chronically uremic rat: II. In vivo glucose utilization

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The sub-totally nephrectomized chronically uremic rat has been found to have significantly increased hepatic glucose-6-phosphate dehydrogenase activity and increased lipogenesis and glycoprotein synthesis. Increased conversion of 14C-D-glucose to 14CO2, and increased plasma free fatty acid levels were also observed. The metabolic significance of these findings has been discussed, particularly with respect to the importance of the pentose shunt in this model. The influence of reduced diet intake, resulting from uremic anorexia, has been considered in light of changes observed. It is concluded that decreased food intake alone is unlikely to be responsible for the altered glucose utilization evident in this model.

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Cited by (0)

1

Department of Biochemistry, University of Dacca, Bangladesh.

2

Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta.

3

Department of Medicine and the Surgical Medical Research Institute, Edmonton, Alta.

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