Demonstration of the compatibility of narrow-bore packed column high-performance liquid chromatography with conventional detection systems
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Measurement of urinary catecholamines in small samples for mice
2013, Journal of Pharmacological and Toxicological MethodsCitation Excerpt :This procedure is quick, cost-effective, and can readily be implemented into any experiment which endeavors to measure sympathetic activity. Additional savings, speed, and sensitivity could be obtained through alterations to the HPLC apparatus, for example via employment of a narrow bore column (Janiszewski, Fouda, & Cole, 1995; Mallett & Law, 1991). While the sensitivity in this particular extraction procedure is a non-issue, considering catecholamine levels were 216 times the limit of detection in the lowest sample, further refinement of the procedure in this way may allow for further miniaturization of the required collection volume.
Application of microbore HPLC in combination with tandem MS for the quantification of rosuvastatin in human plasma
2006, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life SciencesCitation Excerpt :Such columns should, in theory, provide a gain in mass sensitivity over a conventional 4.6 mm HPLC column that is proportional to the square of the reduction factor of the internal diameter of the column employed. Experiments performed with columns of different dimensions have demonstrated an increase in mass sensitivity when using 1.0 mm i.d. columns compared to 4.6 mm i.d. columns of 17-fold [2] and 16–18-fold [3]. The gains in mass sensitivity were slightly lower than the 21-fold predicted, possibly as a result of extra column effects such as band broadening.
Kinetics of the acidic and enzymatic hydrolysis of benazepril HCl studied by LC
2002, Journal of Pharmaceutical and Biomedical AnalysisSimultaneous determination of benazepril hydrochloride and hydrochlorothiazide by micro-bore liquid chromatography
1999, Journal of Pharmaceutical and Biomedical AnalysisAssessment of injection volume limits when using on-column focusing with microbore liquid chromatography
1997, Journal of Chromatography ADevelopment and validation of a high-sensitivity assay for an antipsychotic agent, CP-88,059, with solid-phase extraction and narrow-bore high-performance liquid chromatography
1995, Journal of Chromatography B: Biomedical Sciences and Applications