FocusPlant microtubule inhibitors against trypanosomatids
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Cited by (29)
Anti-trypanosomal activity of cationic N-heterocyclic carbene gold(I) complexes
2017, Molecular and Biochemical ParasitologyCitation Excerpt :Thus, the T. brucei cytoskeleton can be a suitable target for new anti-trypanosomal drugs. Tubulin binders like trifluralin, colchicine and vinblastine displayed potent activity against trypanosomes, but are not sufficiently selective for tubulin of the parasite [16,17]. However, progress has been made to identify highly selective tubulin inhibitors in trypanosomes [18].
The Cytoskeleton and Motility in Apicomplexan Invasion
2003, Advances in ParasitologyCitation Excerpt :Gregarines of the genus Selenidium have a similar arrangement of subpellicular mt, but these were shown to be susceptible to destruction by colchicine or urea, and as a consequence the parasites became motionless (Schrevel et al., 1974). Incubation with dinitroaniline compounds, which may prevent mt polymerisation (Stokkermans et al., 1996; Shaw et al., 2000; Morrissette and Sibley, 2002b) or may depolymerise mt in plants and protozoa (Chan and Fong, 1994; Kaidoh et al., 1995), reduced the invasion rates of both C. parvum sporozoites and P. falciparum merozoites (Wiest et al., 1993; Fowler et al., 1998). The effect of mt disruption on invasion may have been indirect by preventing migration of micronemes to the apical tip of the parasite (Morrissette and Sibley, 2002b; Bannister et al., 2003; G. Margos and colleagues, unpublished observations).
Dinitroaniline herbicides against protozoan parasites: The case of Trypanosoma cruzi
2001, Trends in ParasitologyExpression of Giardia duodenalis β-tubulin as a soluble protein in Escherichia coli
2001, Protein Expression and PurificationProtist tubulins: New arrivals, evolutionary relationships and insights to cytoskeletal function
2001, Current Opinion in Microbiology