A new anticancer compound interferes with aurora kinases, regulators of mitosis. We can now hope for the biology of these kinases to inform clinical trials (pages 262–267).
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Aurora kinases are expressed in medullary thyroid carcinoma (MTC) and their inhibition suppresses in vitro growth and tumorigenicity of the MTC derived cell line TT
BMC Cancer Open Access 26 September 2011
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Harrington, E.A. et al. Nat. Med. 10, 262–267 (2004).
Carmena, M. & Earnshaw, W.C. Nat. Rev. Mol. Cell Biol. 4, 842–854 (2003).
Hauf, S. et al. J. Cell Biol. 161, 281–294 (2003).
Ditchfield, C. et al. J. Cell Biol. 161, 267–280 (2003).
Kapoor, T.M., Mayer, T.U., Coughlin, M.L. & Mitchison, T.J. J. Cell Biol. 150, 975–988 (2000).
Johnson, R.K. et al. Proc. Am. Assoc. Cancer Res. 43, 269 (2002).
Johnson, J.I. et al. Br. J. Cancer 84, 1424–1431 (2001).
Baguley, B.C. & Marshall, E.S. Eur. J. Cancer (in the press).
Kuh, H.J., Jang, S.H., Wientjes, M.G. & Au, J.L.-S. J. Phamacol. Exp. Ther. 293, 761–770 (2000).
Dancey, J. & Sausville, E.A. Nat. Rev. Drug Discov. 2, 296–313 (2003).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sausville, E. Aurora kinases dawn as cancer drug targets. Nat Med 10, 234–235 (2004). https://doi.org/10.1038/nm0304-234
Issue Date:
DOI: https://doi.org/10.1038/nm0304-234
This article is cited by
-
Synthesis and investigation of new Hesperadin analogues antitumor effects on HeLa cells
Journal of Chemical Biology (2014)
-
Aurora kinases are expressed in medullary thyroid carcinoma (MTC) and their inhibition suppresses in vitro growth and tumorigenicity of the MTC derived cell line TT
BMC Cancer (2011)
-
Phospho-regulation of human protein kinase Aurora-A: analysis using anti-phospho-Thr288 monoclonal antibodies
Oncogene (2006)
-
Aurora kinases: shining lights on the therapeutic horizon?
Oncogene (2005)
-
Characterization of gene expression in mucinous cystic neoplasms of the pancreas using oligonucleotide microarrays
Oncogene (2004)