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A 2D crossover–based map of the human X chromosome as a model for map integration

Nature Genetics volume 9, pages 261–266 (1995)Cite this article

Abstract

We have contructed a two–dimensional map of 243 markers on the X chromosome. The average distance between markers ordered by two recombinants is 5.4 centiMorgans(cM), which is reduced to 3.2 cM using a less stringent criterion of one recombinant. Map resolution is enhanced by replacing the usual reference marker format with a 2D format, and the two–recombinant rule is more conservative than the lod 3.0 criterion for order. Taken together, crossover mapping and the 2D format produces maps with greater reliability and higher resolution than maps constructed using currently accepted standards. This first high–density crossover–based map of an entire human chromosome provides a model for integrating physical and genetic maps.

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Authors and Affiliations

  1. Department of Medical Informatics, University of Utah, Salt Lake City, Utah, 84108, USA

    Pamela R. Fain, Edward N. Kort, Kim Nguyen & Douglas F. Redd

  2. Division of Neurology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, 19104, USA

    Phillip F. Chance

  3. Division of Endocrinology, Metabolism and Nutrition, Duke University School of Medicine, Durham, North Carolina, 27710, USA

    Michael J. Econs

  4. Department of Physiology, University of Utah, Salt Lake City, Utah, 84108, USA

    David F. Barker

Authors
  1. Pamela R. Fain
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  2. Edward N. Kort
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  3. Phillip F. Chance
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  4. Kim Nguyen
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  5. Douglas F. Redd
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  6. Michael J. Econs
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  7. David F. Barker
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Fain, P., Kort, E., Chance, P. et al. A 2D crossover–based map of the human X chromosome as a model for map integration. Nat Genet 9, 261–266 (1995). https://doi.org/10.1038/ng0395-261

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