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Has the chimpanzee Y chromosome been sequenced?

Nature Genetics volume 38, pages 853–854 (2006)Cite this article

To the Editor:

Kuroki et al. recently reported “the finished sequence of the chimpanzee Y chromosome”1. Their analyses included comparisons with previously reported DNA sequences from the human and chimpanzee Y chromosomes2,3. The article1 was based on the authors' sequencing of 12.7 Mb from the PTB1 library, which represents the genome of one male chimpanzee. We previously sequenced the 9.5-Mb 'X-degenerate' portion of the Y chromosome from a different male chimpanzee, whose genome is represented in the CHORI-251 library2. We write to express concerns regarding the conclusions of Kuroki et al., including the gene content of the chimpanzee and human Y chromosomes, and the level of sequence divergence between the two chimpanzee Y chromosomes whose sequences have been explored.

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References

  1. Kuroki, Y. et al. Nat. Genet. 38, 158–167 (2006).

    Article  CAS  Google Scholar 

  2. Hughes, J.F. et al. Nature 437, 100–103 (2005).

    Article  Google Scholar 

  3. Skaletsky, H. et al. Nature 423, 825–837 (2003).

    Article  CAS  Google Scholar 

  4. Yen, P. Nat. Genet. 29, 243–244 (2001).

    Article  CAS  Google Scholar 

  5. Kuroda-Kawaguchi, T. et al. Nat. Genet. 29, 279–286 (2001).

    Article  CAS  Google Scholar 

  6. Rozen, S. et al. Nature 423, 873–876 (2003).

    Article  CAS  Google Scholar 

  7. Hurles, M.E. & Jobling, M.A. Nat. Genet. 34, 246–247 (2003).

    Article  CAS  Google Scholar 

  8. Anonymous. Nat. Genet. 35, 195 (2003).

  9. Tyler-Smith, C. & McVean, G. Nat. Genet. 35, 201–202 (2003).

    Article  CAS  Google Scholar 

  10. Repping, S. et al. Nat. Genet. 35, 247–251 (2003).

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Howard Hughes Medical Institute, Whitehead Institute,

    Jennifer F Hughes, Helen Skaletsky, Steve Rozen & David C Page

  2. Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, 02142, Massachusetts, USA

    Jennifer F Hughes, Helen Skaletsky, Steve Rozen & David C Page

  3. Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, St. Louis, 63108, Missouri, USA

    Richard K Wilson

Authors
  1. Jennifer F Hughes
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  2. Helen Skaletsky
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  3. Steve Rozen
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  4. Richard K Wilson
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  5. David C Page
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Corresponding author

Correspondence to David C Page.

Supplementary information

Supplementary Figure 1

Alignment of partial sequences of human C24L4 genomic DNA, human CD24 cDNA, and Invitrogen human cDNA clones.

Supplementary Table 1

Supplementary Table 2

Supplementary Table 3

Supplementary Note

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Hughes, J., Skaletsky, H., Rozen, S. et al. Has the chimpanzee Y chromosome been sequenced?. Nat Genet 38, 853–854 (2006). https://doi.org/10.1038/ng0806-853b

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