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Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23

Nature Genetics volume 31, pages 133–134 (2002)Cite this article

Abstract

We found that PPM1D, encoding a serine/threonine protein phosphatase, lies within an epicenter of the region at 17q23 that is amplified in breast cancer. We show that overexpression of this gene confers two oncogenic phenotypes on cells in culture: attenuation of apoptosis induced by serum starvation and transformation of primary cells in cooperation with RAS.

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Figure 1: APPBP2/PPM1D amplicon characterization, assays for APPBP2 and PPM1D oncogenic function and detection of PPM1D protein in breast cancer cell lines.

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Acknowledgements

We thank Jodi Harris for preparation of the figures.

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Authors and Affiliations

  1. Genomics Division, Tularik Inc., 266 Pulaski Road, Greenlawn, New York, USA

    Jing Li, Ying Yang, Yue Peng, Winfried G. van Eyndhoven, Ken C. Q. Nguyen & Scott Powers

  2. Tularik Inc., South San Francisco, California, USA

    Richard J. Austin, Tim Gabriele & Timothy Hoey

  3. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA

    Mila E. McCurrach & Scott W. Lowe

  4. Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA

    Jeffrey R. Marks

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  1. Jing Li
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  2. Ying Yang
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  3. Yue Peng
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  4. Richard J. Austin
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  5. Winfried G. van Eyndhoven
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  7. Tim Gabriele
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Correspondence to Scott Powers.

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The authors declare no competing financial interests.

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Li, J., Yang, Y., Peng, Y. et al. Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23. Nat Genet 31, 133–134 (2002). https://doi.org/10.1038/ng888

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