Abstract
Stedman and Stedman have stated in a recent issue of NATURE1 that the presence of acetoacetate leads to acetylcholine synthesis in the brain. The evidence for this conclusion is apparently the fact that the rate of acetylcholine formation by brain tissue macerated in the presence of chloroform and eserine and incubated at 37° is increased on the addition of sodium acetoacetate to the macerate.
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References
Stedman and Stedman, NATURE, 141, 39 (1938).
See also Quastel, Tennenbaum and Wheatley, Biochem. J., 30, 1668 (1936).
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MANN, P., TENNENBAUM, M. & QUASTEL, J. Mechanism of the Biological Synthesis of Acetylcholine. Nature 141, 374 (1938). https://doi.org/10.1038/141374a0
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DOI: https://doi.org/10.1038/141374a0
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