Abstract
MANY attempts have been made to obtain from immune sera, substances carrying the antibody function. Protein solutions specifically precipitable to the extent of 40–60 per cent (nitrogen precipitated by pneumococcus specific polysaccharide/total nitrogen) have thus been prepared by the Felton method1. By dissociation of specific precipitates with strong sodium chloride, antibody solutions precipitable to the extent of 90 per cent have been prepared2. An investigation of the physico-chemical properties of these systems, especially of those bearing upon chemical homogeneity and the relation to the components of normal sera, would seem to be of interest.
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References
L. D. Felton, J. Immunology, 21, 357 (1931), and other papers.
M. Heidelberger and F. E. Kendall, J. Exp. Med., (Aug. 1936).
See for example, T. Svedberg, Chem. Rev., 14, 1 (1934); Kolloid Z., 67, 2 (1934).
A. Tiselius, Nova Acta Reg. Soc. Scient. Upsaliensis, Ser. IV, 7, No. 4. See also Pedersen, K.O., Kolloid Z., 63, 268 (1933).
M. Heidelberger and F. E. Kendall, J. Exp. Med., 61, 559 (1935); P. 570.
W. J. Elford, P. Grabar and W. Fischer, Biochem. J., 30, 92 (1936). As this goes to press we note also very similar sedimentation constants obtained by J. Biscoe, F. Herik and R. W. G. Wyckoff, Science, June 19, 1936.
M. Heidelberger and F. E. Kendall, J. Exp. Med., 50, 809 (1929); and subsequent papers.
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HEIDELBERGER, M., PEDERSEN, K. & TISELIUS, A. Ultracentrifugal and Electrophoretic Studies on Antibodies. Nature 138, 165 (1936). https://doi.org/10.1038/138165a0
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DOI: https://doi.org/10.1038/138165a0
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