Abstract
THE carcinogenic hydrocarbon 7,12-dimethylbenz-[α]anthracene (DMBA) inhibits the incorporation of tritiated thymidine into the deoxyribonucleic acid (DNA) of the cells of the growing hair follicle of the mouse to the extent of approximately 50 per cent in 24 hr.1. We have now examined the effect of this hydrocarbon on the timing of the phases of the pro-liferative cycle of these cells.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
McCarter, J. A., and Quastler, H., Biochim. Biophys. Acta, 55, 553 (1962).
Chase, H., Physiol. Rev., 34, 113 (1954).
McCarter, J. A., J. Nat. Cancer Inst., 17, 399 (1956).
Ball, J. K., and McCarter, J. A., Brit. J. Cancer, 14, 577 (1960).
Howard, A., and Pelc, S. R., Heredity, Supp. 6, 261 (1953).
Quastler, H., and Sherman, F. G., Exp. Cell Res., 17, 420 (1959).
Cattaneo, S. M., Quastler, H., and Sherman, F. G., Nature, 190, 923 (1961).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
McCARTER, J., QUASTLER, H. Effect of Dimethylbenzanthracene on the Cellular Proliferation Cycle. Nature 194, 873–874 (1962). https://doi.org/10.1038/194873a0
Issue Date:
DOI: https://doi.org/10.1038/194873a0
This article is cited by
-
Differentiation of the mammary gland and susceptibility to carcinogenesis
Breast Cancer Research and Treatment (1982)
-
Zur DNS-Synthesezeit in der menschlichen Epidermis
Archiv f�r Klinische und Experimentelle Dermatologie (1967)
-
Inhibition by a Carcinogenic Hydrocarbon of Incorporation of Tritiated Cytidine into Mouse Epidermal Cells
Nature (1964)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.