Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Role of C′4 in the Antiglobulin Reaction

Nature volume 186, pages 482–483 (1960)Cite this article

Abstract

WHEN human red cells are incubated with fresh serum containing a complement-binding blood-group antibody, they become agglutinable by an anti-‘non-γ’ globulin serum, that is, a serum reacting with human globulins other than γ-globulin1–3. In such cases the antiglobulin serum reacts with complement (C′) rather than with the blood-group antibody4.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Dacie, J. V., Lancet, ii, 954 (1951).

  2. Mollison, P. L., and Cutbush, Marie, Lancet, i, 1290 (1955).

  3. Cutbush, Marie, Crawford, Hal, and Mollison, P. L., Brit. J. Hæmatol., 1, 410 (1955).

    Article  CAS  Google Scholar 

  4. Dacie, J. V., Crookston, J. H., and Christenson, W. N., Brit. J. Hæmatol., 3, 77 (1957).

    Article  CAS  Google Scholar 

  5. Mayer, M. M., and Levine, L., J. Immunol., 72, 516 (1954).

    CAS  PubMed  Google Scholar 

  6. Levine, L., Mayer, M., and Rapp, H. J., J. Immunol., 73, 435 (1954).

    CAS  Google Scholar 

  7. Coombs, A. M., and Coombs, R. R. A., J. Hygiene, 51, 509 (1953).

    Article  CAS  Google Scholar 

  8. Gandini, E., “Bibliotheca Haematol.”, Fasc. 10 (1959).

    Google Scholar 

  9. Pillemer, L., Ecker, E. E., Oncley, J. L., and Cohn, E. J., J. Exp. Med., 74, 297 (1941).

    Article  CAS  Google Scholar 

  10. Mollison, P. L., and Polley, Margaret J., J. Immunol., 3, 11 (1960).

    CAS  Google Scholar 

  11. Becker, E. L., Fed. Proc., 18, 557 (1959).

    Google Scholar 

  12. Coombs, R. R. A., Blomfield, A. M., and Roberts, G. F., J. Hygiene, 48, 484 (1950).

    Article  CAS  Google Scholar 

  13. Mayer, M. M., Levine, L., Rapp, H. J., and Morncei, A. A., J. Immunol., 73, 443 (1954).

    CAS  PubMed  Google Scholar 

  14. Ellis, H. A., and Gell, P. G. H., Nature, 181, 1667 (1958).

    Article  ADS  CAS  Google Scholar 

  15. Matuhasi, T., and Usui, M., Med. and Biol., 46, 258 (1958).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Medical Research Council Blood Transfusion Research Unit, Postgraduate Medical School of London, Ducane Road, London, W.12

    G. C. JENKINS, MARGARET J. POLLEY & P. L. MOLLISON

Authors
  1. G. C. JENKINS
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. MARGARET J. POLLEY
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P. L. MOLLISON
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

JENKINS, G., POLLEY, M. & MOLLISON, P. Role of C′4 in the Antiglobulin Reaction. Nature 186, 482–483 (1960). https://doi.org/10.1038/186482a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/186482a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing