Abstract
IT is known that the different acridine derivatives are able to become bound to isolated nucleic acids1. The compounds are more strongly bound by the highly polymerized deoxyribonucleic acid than by the ribonucleic acid1. The results of studying the interactions with deoxyribonucleic acid and the strong antibacterial effects of nitroacridine2 suggest that these compounds may be used as virus chemotherapeutic agents.
Similar content being viewed by others
Article PDF
References
Irvin, J. L., and Irvin, E. M., J. Biol. Chem., 206, 39 (1954).
Schnitzer, R., and Silberstein, W., Z. Hyg. Infektionskrankh., 109, 519 (1929).
Hershey, A. D., and Chase, M., J. Gen. Physiol., 36, 39 (1952).
De Mars, R. I., Virology, 1, 83 (1955).
Hershey, A. D., Dixon, J., and Chase, M., J. Gen. Physiol., 36, 777 (1953).
Vidaver, G. A., and Kozloff, L. M., J. Biol. Chem., 225, 335 (1957).
Hershey, A. D., The Harvey Lectures, 51, 229 (1957).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
DÉNES, G., POLGÁR, L. Effect of Nitroacridine 3663 on Synthesis of Deoxyribonucleic Acid and Multiplication of T 2 Phage. Nature 185, 386 (1960). https://doi.org/10.1038/185386a0
Issue Date:
DOI: https://doi.org/10.1038/185386a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.