Abstract
IT has previously been reported1,2 that chlorothiazide and its saturated derivative, hydrochlorothiazide, have a substantial and sustained antidiuretic effect in diabetes insipidus, both experimental and clinical. The antidiuretic activity of unit weight of hydrochlorothiazide, and of its trifluoromethyl and benzyltrifluoromethyl analogues (hydrofluomethiazide and FT81), is many times greater than that of chlorothiazide.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Crawford, J. D., and Kennedy, G. C., Nature, 183, 891 (1959).
Kennedy, G. C., and Crawford, J. D., Lancet, i, 866 (1959).
Buell, M. V., and Turner, E., Amer. J. Physiol., 134, 225 (1941).
Harrop, G. A., Soffer, L. J., Nicholson, W. M., and Strauss, M., J. Exp. Med., 61, 839 (1934).
Allers, W. D., Proc. Mayo Clin., 10, 406 (1935).
Robinson, F. J., Power, M. H., and Kepler, E. J., Proc. Mayo Clin., 16, 577 (1941).
Gaunt, R., Birnie, J. H., and Eversole, W. J., Physiol. Rev., 29, 281 (1949).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
KENNEDY, G., CRAWFORD, J. An Antimineralocorticoid Action of some Saluretic Sulphonamides. Nature 184, 1492–1493 (1959). https://doi.org/10.1038/1841492a0
Issue Date:
DOI: https://doi.org/10.1038/1841492a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
