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Lack of Direct Effect of Erythropoietin on Human Erythroid Cells in vitro

Nature volume 184, pages 1228–1229 (1959)Cite this article

Abstract

THE existence in the plasma and urine of anæmic patients and animals, of a substance which is capable of increasing the rate of production of red cells in normal recipients is now an undisputed fact. However, the mechanism by which this substance exerts its stimulatory effect is still obscure. Two mechanisms for its action can be postulated. A direct action of the hormone on erythroid cells to stimulate rate of cell division as well as rate of differentiation, that is to say, hæmoglobinization, would increase the rate of turnover of marrow. Alternatively the hormone could accelerate the rate of differentiation of stem cells into the erythron to expand the volume of active marrow without affecting the rate of turnover.

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References

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Authors and Affiliations

  1. Radiobiology Laboratory, Department of Radiotherapy, University of Oxford,

    EDWARD L. ALPEN & L. G. LAJTHA

  2. Donner Laboratory, University of California, Berkeley, California

    DONALD C. VAN DYKE

Authors
  1. EDWARD L. ALPEN
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  2. L. G. LAJTHA
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  3. DONALD C. VAN DYKE
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ALPEN, E., LAJTHA, L. & VAN DYKE, D. Lack of Direct Effect of Erythropoietin on Human Erythroid Cells in vitro . Nature 184, 1228–1229 (1959). https://doi.org/10.1038/1841228a0

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