Abstract
PREVIOUS studies with mitomycin C, a new antibiotic isolated from Streptomyces caespitosus by Wakaki et al., have demonstrated antibacterial activity as well as a marked antitumour effect1,2. In the course of investigating the mechanism of the actions of mitomycin C, evidence was obtained that this antibiotic selectively inhibits the synthesis of deoxyribonucleic acid in Escherichia coli B.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Wakaki, S., et. al., Antib. and Chemo., 8, 228 (1958).
Hata, T., et al., J. Antib., Ser. A, 9, 141 (1956).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
SHIBA, S., TERAWAKI, A., TAGUCHI, T. et al. Selective Inhibition of Formation of Deoxyribonucleic Acid in Escherichia coli by Mitomycin C . Nature 183, 1056–1057 (1959). https://doi.org/10.1038/1831056a0
Issue Date:
DOI: https://doi.org/10.1038/1831056a0
This article is cited by
-
A dual-targeting approach to inhibit Brucella abortus replication in human cells
Scientific Reports (2016)
-
Thymidine incorporation as a measure of heterotrophic bacterioplankton production in marine surface waters: Evaluation and field results
Marine Biology (1982)
-
Coupling between the initiation of DNA replication and cell division in the blue-green alga Anacystis nidulans
Archives of Microbiology (1977)
-
Effect of bleomycin on the fine structure of mouse fibroblasts
Zeitschrift f�r Krebsforschung und Klinische Onkologie (1976)
-
Influence of edeine on intergenic and interallelic recombination in Neurospora crassa
Molecular and General Genetics MGG (1975)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.