Abstract
SYNTHETIC polysaccharides can be prepared from simple carbohydrates differing not only in molecular weight but also in degree of branching1. From such polyglucoses, various charged derivatives can be prepared, for example, a series of sulphuric acid esters with different degrees of sulphonation. The synthetic polysaccharide derivatives provide a system of ‘macro-anions’ the composition, macromolecular and polyelectrolyte properties of which can be altered systematically. Interaction of other kinds of macro-anions with certain proteins and polypeptides had been found to: alter solubility and thus make possible development of new fractionation and preparative methods2; inhibit, often reversibly, a large number of enzymes3; and show some similarity to antigen–antibody precipitation.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Mora, P. T., et al., J. Amer. Chem. Soc., 80, 685, 693 (1958); J. Polymer Sci., 23, 345 (1957).
Cf. Morawetz, H., and Hughes, jun., W. L., J. Phys. Chem., 56, 64 (1952). Oncley, J. L., Walton, K. W., and Cornwell, D. G., J. Amer. Chem. Soc., 79, 4666 (1957).
Cf. Spensley, P. C., and Rogers, H. J., Nature, 173, 1190 (1954).
Vandendriessche, L., Arch. Biochem. Biophys., 65, 347 (1956).
Skarnes, R. C., and Watson, D. W., J. Bacteriol., 70, 110 (1955).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
MORA, P., YOUNG, B. Interaction between Synthetic Polyglucose Sulphate and Biologically Active Basic Polypeptides and Proteins. Nature 181, 1402–1403 (1958). https://doi.org/10.1038/1811402a0
Issue Date:
DOI: https://doi.org/10.1038/1811402a0
This article is cited by
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.