Abstract
THAT embryonic tissues in vitro may be affected more drastically by fractionated, than by single, doses of X-rays was shown by Spear in 1932 1. Working with chick embryo fibroblasts, he demonstrated that the depression of activity of these cells is far greater with two 2½-min. exposures separated by 80 min. than with a single 5-min. exposure. In view of the possible significance of these findings for our understanding of the nature of embryonic damage resulting from X-irradiation, and in view of the general interest in the question of radiation hazards to the developing mammalian embryo, the present experiment was designed to determine whether there is a difference between the effects of single and fractionated doses of X-rays on developing mouse embryos in vivo.
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References
Spear, F. G., Proc. Roy. Soc., B, 110, 224 (1932).
Russell, L. B., J. Exp. Zool., 114, 545 (1950). Auerbach, R., Anat. Rec., 121, 258 (1955).
Russell, L. B., and Russell, W. L., J. Cell. Comp. Phys., 43, Supp. 1, 103 (1954).
Russell, L. B., and Russell, W. L., Radiology, 58, 369 (1952).
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AUERBACH, R. Effects of Single and Fractionated Doses of X-Rays on Mouse Embryos. Nature 177, 574 (1956). https://doi.org/10.1038/177574a0
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DOI: https://doi.org/10.1038/177574a0
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