Abstract
THE observations of Peters et al. 1 that the administration of fluorocitrate resulted in the inhibition of the tricarboxylic acid cycle suggested the synthesis of other fluorinated acids of biochemical interest. In this preliminary communication, we wish to report the synthesis of (±) methyl fluoromalate and fluoromalamide.
Similar content being viewed by others
Article PDF
References
Peters, R. A., Wakelin, R. W., and Buffa, P., Biochem. J., Proc. xiii, 50 (1952).
Rivett, D. E., J. Chem. Soc., 3710 (1953).
Claisen, Ber., 47, 2031 (1914).
Gal, E. M., Peters, R. A., and Wakelin, R. W., Proc. Biochem. Soc. (to be published).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
TAYLOR, N., KENT, P. Synthesis of (±) Methyl Fluoromalate. Nature 174, 401 (1954). https://doi.org/10.1038/174401a0
Issue Date:
DOI: https://doi.org/10.1038/174401a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.