Abstract
SEEGERS et al. 1 have very recently made an analysis on the amino-acid content, particularly tyrosine and tryptophan, of purified prothrombin. They have also shown by electrophoresis that their prothrombin preparation contains approximately 90 per cent of the protein in one component1. Several other workers2–4 have investigated the nature of the protein in prothrombin. Astrup and Darling4 have reported prothrombin to be a protein of globulin character. But the complete analysis of the prothrombin molecule with respect to different amino-acid contents is lacking.
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References
Seegers, W. H., McClaughry, R. I., and Fahey, J. L., Blood, 5, 421 (1950).
Quick, A. J., Amer. J. Physiol., 151, 63 (1947).
Sorbye, O., Kruse, I., and Dam, H., Acta Chem. Scand., 4, 549, 831 (1950).
Astrup, T., and Darling, S., Acta Physiol. Scand., 5, 97 (1943).
Giri, K. V., and Rao, N. A. N., J. Ind. Inst. Sci., 34, 95 (1952).
Seegers, W. H., Loomis, E. C., and Vandenbelt, J. M., Arch. Biochem., 6, 85 (1945).
Ware, A. G., and Seegers, W. H., Amer. J. Clin. Path., 19, 471 (1949).
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RAY, G., GANGULI, N. & ROY, S. Identification of Amino-Acids Present in Purified Prothrombin by Circular Paper Chromatography. Nature 172, 809–810 (1953). https://doi.org/10.1038/172809b0
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DOI: https://doi.org/10.1038/172809b0
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