Abstract
Vasoactive intestinal polypeptide (VIP) is known to have powerful effects on the secretion from several endocrine and exocrine glands1–3, and occurs in nerves with a ubiquitous distribution in the body4,5. This infers that neuronal VIP may be a regulator of such secretion, and there is evidence that it is involved in the regulation of exocrine pancreatic function3. Previous studies have shown that adrenergic and cholinergic nerves participate in the regulation of thyroid hormone secretion6–9. We describe here combined immunohistochemical and immunochemical studies which show that the thyroid of several species is supplied with VIP-containing nerve fibres that surround blood vessels and run between and along thyroid follicles and that in the mouse neuronal VIP participates in the regulation of thyroid hormone secretion through a mechanism that is mediated by cyclic AMP.
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Ahrén, B., Alumets, J., Ericsson, M. et al. VIP occurs in intrathyroidal nerves and stimulates thyroid hormone secretion. Nature 287, 343–345 (1980). https://doi.org/10.1038/287343a0
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DOI: https://doi.org/10.1038/287343a0
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