Abstract
MURINE T lymphocytes that mediate the lysis of virus-infected cells show specificity both for the viral cell surface antigens and for the H–2K or D antigens of the major histo-compatibility complex1–8. The cytotoxic T lymphocytes and the target cell must share H–2K or D products. The experiments reported here demonstrate that there is a similar requirement for partial HLA identity between human cytotoxic lymphocytes and influenza virus-infected target cells.
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References
Doherty, P. C., Blanden, R. V. & Zinkernagel, R. M. Transplant. Rev. 29, 89–124 (1976).
Koszinowski, U. & Ertl, H. Nature 255, 552–554 (1975).
Blanden, R. V. et al. Nature 254, 269–270 (1975).
Doherty, P. C. & Zinkernagel, R. M. Immunology 31, 27–32 (1976).
Zweerink, H. J., Courtneidge, S. A., Skehel, J. J., Crumpton, M. J. & Askonas, B. A. Nature 267, 354–356 (1977).
Yap, K. L. & Ada, G. L. Immunology 32, 151–160 (1977).
Effros, R. B., Doherty, P. C., Gerhard, W. & Bennink, J. J. exp. Med. 145, 557–568 (1977).
Doherty, P. C., Efros, R. B. & Bennink, J. Proc. natn. Acad. Sci. U.S.A. 74, 1209–1213 (1977).
Zweerink, H. J., Askonas, B. A., Millican, D., Courtneidge, S. A. & Skehel, J. J. Eur. J. Immun. (in the press).
Simpson, E., Gordon, R., Taylor, M., Mertin, J. & Chandler, P. Eur. J. Immun. 5, 451–455 (1975).
Bodmer, J. et al. Tissue Antigens 8, 359–371 (1976).
Histocompatibility Testing 1975. (ed. F. Kissmeyer-Nielssen) (Munksgaard, Copenhagen, 1976).
Zinkernagel, R. M. & Doherty, P. C. Nature 251, 547–548 (1974).
Hood, L. in The Role of Products of the Histocompatibility Gene Complex in human responses. (ed. D. H. Katz & B. Benacerraf) 703–705 (Academic, London, 1976).
Goulmy, E., Termijtelen, A., Bradley, B. A. & Van Rood, J. J. Nature 266, 544–545 (1977).
Zinkernagel, R. M. J. exp. Med. 143, 437–443 (1976).
Jondal, M., Svedmyr, E., Klein, E. & Singh, S. Nature 255, 405–407 (1975).
Ewan, P. & Lachmann, P. Clin. exp. Immun. (in the press).
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MCMICHAEL, A., TING, A., ZWEERINK, H. et al. HLA restriction of cell-mediated lysis of influenza virus-infected human cells. Nature 270, 524–526 (1977). https://doi.org/10.1038/270524a0
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DOI: https://doi.org/10.1038/270524a0
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