Abstract
THE substance called epidermal chalone contained in normal mammalian epidermis is known to inhibit mitosis in a tissue specific manner1–3. The chalone is heat labile and nondialysable; it is precipitated by ethanol and can be preserved in a lyophilized form4. It appears5 to be a glycoprotein of molecular weight between 25,000 and 30,000. Aqueous extracts and a partially purified ethanol fraction of the skin of man, mouse, cod and pig inhibit mitosis in vitro and in vivo4,6,7. Similar extracts from other tissues do not affect mitosis in the epidermis8–12.
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References
Bullough, W. S., and Laurence, E. B., Exp. Cell Res., 24, 289 (1961).
Bullough, W. S., Hewett, C. L., and Laurence, E. B., Exp. Cell Res., 36, 192 (1961).
Iversen, O. H., Ciba Foundation Symp. Homeostatic Regulators (edit. by Wolstenholme, G. E. W., and Knight, J.), 29 (Churchill, London, 1969).
Bullough, W. S., and Laurence, E. B., in Adv. Biol. Skin, 7 (edit. by Montana, W., and Dobson, R. L.) (Pergamon, New York, 1965).
Boldingh, W. H., and Laurence, E. B., Europ. J. Biochem., 5, 191 (1968).
Bullough, W. S., Laurence, E. B., Iversen, O. H., and Elgjo, K., Nature, 214 (1967).
Iversen, O. H., Aandahl, E., and Elgjo, K., Acta Pathol. Microbiol. Scand., 64, 506 (1965).
Rytomaa, T., and Kiviniemi, K., Cell Tissue Kinetics, 1, 329 (1968).
Saetren, H. A., Exp. Cell Res., 11, 229 (1956).
Simnett, J. D., and Chopra, D. P., Nature, 222, 1189 (1969).
Voaden, M. J., and Leeson, S. J., Exp. Eye Res., 9, 57 (1970).
Volm, M., Kinzel, V., Mohr, U., and Suss, R., Experientia, 25, 68 (1969).
Bullough, W. S., The Evolution of Differentiation (Academic Press, London, 1967).
Bullough, W. S., and Laurence, E. B., Europ. J. Cancer, 4 (1968).
Schmidt, O., Naturwissenschaften, 29, 146 (1941).
Heidelberger, C., J. Cell Comp. Physiol., 64, Suppl. 1, 129 (1964).
Miller, E. C., Cancer Res., 11, 100 (1951).
Miller, J. A., and Miller, E. C., Adv. Cancer Res., 1, 339 (1953).
Miller, E. C., and Miller, J. A., Cancer Res., 12, 547 (1952).
Sorof, S., Young, E. M., and Fetterman, P. L., Exp. Cell Res., 20, 253 (1960).
Bullough, W. S., Biol. Rev., 37, 307 (1962).
Bullough, W. S., and Laurence, E. B., Proc. Roy. Soc., B, 151, 517 (1960).
Wiest, W. G., and Heidelberger, C., Cancer Res., 13, 246 (1953).
Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., J. Biol. Chem., 193, 265 (1951).
Patterson, M. S., and Greene, R. C., Anal. Chem., 37, 854 (1965).
Matsushita, H., Suzuki, Y., and Shakabe, H., Bull. Chem. Soc., Japan, 36, 13711 (1963).
Panyim, S., and Chalkley, R., Arch. Biochem. Biophys., 130, 337 (1969).
Reisfeld, R. A., Lewis, U. J., and Williams, D. E., Nature, 195, 281 (1962).
Clarke, J. T., Ann. NY Acad. Sci., 121, 428 (1964).
Peter, V., Thishler, and Epstein, C. J., Anal. Biochem., 22, 89 (1968).
Abell, C. W., and Heidelberger, C., Cancer Res., 22, 931 (1962).
Mohr, U., Althoff, J., Kimzel, V., Suss, R., and Volm, M., Nature, 220, 138 (1968).
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BISHAI, I., MOSCARELLO, M. & RITCHIE, A. Dimethylbenzanthracene Binding to Epidermal Chalone. Nature 232, 114–116 (1971). https://doi.org/10.1038/232114a0
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DOI: https://doi.org/10.1038/232114a0
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