Abstract
THE discovery in 1957 of the therapeutic effect of imipramine in endogenous depression1 stimulated a search for other substances with similar properties, and several drugs which are structurally closely related to imipramine, known collectively as the tricyclic antidepressants, have become available2. The spectrum of antidepressant effects of these drugs is fairly uniform, although some possess tranquillizing activity, which is useful for treating patients whose depression is complicated by agitation3,4. But these substances have side effects which stem partly from anticholinergic and antihistaminic properties5. In the past 5 yr attempts have been made to depart from the tricyclic structures, and antidepressant activity has been claimed for iprindole6, IN 1060 (ref. 7), thiazesim8 and other compounds, but it is too early to assess their place in the therapy of depression.
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References
Kuhn, R., Schweiz. Med. Wochschr., 87, 1135 (1957).
Biel, J. H., Drugs Affecting the Central Nervous System, 2, (edit. by Burger, A.), 61 (Arnold, London, 1968).
Ayd, F. J., Dis. Nerv. Syst. 26, 719 (1965).
Simpson, G. M., and Salim, T., Curr. Ther. Res., 7, 661 (1965).
Sulser, F., Bickel, M. H., and Brodie, B. B., J. Pharmacol. Exp. Ther., 144, 321 (1964). Cairncross, K. D., Gershon, S., and Gust, I. D., J. Neuropsychiat., 4, 224 (1963). Bogdanski, D. F., Sulser, F., and Brodie, B. B., J. Pharmacol. Exp. Ther., 132, 176 (1961). Costa, E., Garattini, S., and Valzelli, L., Experientia, 16, 461 (1960). Domenjoz, R., and Theobald, W., Arch. Intern. Pharmacodyn., 20, 450 (1959). Rathbun, R. C., and Slater, I. H., Psychopharmacologia, 4, 114 (1963).
El Deiry, N. K., Forrest, A. D., and Littmann, S. K., Brit. J. Psychiat., 113, 999 (1967). Johnson, J., and Maden, J. G., Clin. Trials J., 4, 787 (1967).
Sletten, I. W., Pichardo, X., and Gershon, S., Curr. Ther. Res., 7, 609 (1965).
Freeman, H., Otkem, M. R., Kristofferson, M. W., and Gorby, C. K., Curr. Ther. Res., 7, 655 (1965).
Walker, G. N., Smith, R. T., and Weaver, B. N., J. Med. Chem., 8, 626 (1965).
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CANAS-RODRIGUEZ, A., LEEMING, P. N-Phenyl Indoline Derivatives—a New Class of Antidepressant Agents. Nature 223, 75–76 (1969). https://doi.org/10.1038/223075a0
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DOI: https://doi.org/10.1038/223075a0
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