Abstract
AN agglutinin was found1–3 which interacted primarily with neoplastic cells: there were exceptions4 but not among virally transformed malignant cells. Although standard mother tissue cells did not agglutinate, all derivatives transformed by viruses agglutinated in similar conditions5, indicating that the ability of the tumour cell was acquired with viral transformation. The lines so far tested include polyoma virus transformed 3T3, adenovirus 12 transformed BHK and SV40 transformed 3T3 cells. The agglutinin was isolated and purified and, based on hapten inhibition, N-acetylglucosamine (GlcNac) was found to be part of the receptor site5,6.
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BURGER, M. Isolation of a Receptor Complex for a Tumour Specific Agglutinin from the Neoplastic Cell Surface. Nature 219, 499–500 (1968). https://doi.org/10.1038/219499a0
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DOI: https://doi.org/10.1038/219499a0
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