Abstract
FOR a long time1 it has been known that the experimental infection of guinea-pigs could be aggravated by exposure to silica particles. Many surveys have tried to specify the interactions: “dust-infection” into lungs. We have determined the pathogenic role of Mycobacterium kansasii in guinea-pigs exposed to the inhalation of mineral dust particles2–7 and have established the following facts. (a) Dust particles aggravate experimental infection by Mycobacterium kansasii, and dusting is liable to make pathogenic a certain dose of bacteria which, without dust, would not induce lesions. (b) There is increased severity of the pulmonary lesions when there is dusting before, but not after the inoculation of an infecting dose of about 5 × 105 micro-organisms. (c) The previously established absence8–11 of increased virulence of the strains after passage and extensive multiplication in dusted animals is confirmed and so is (d) the exacerbation arid precociousness of tuberculin-allergy after the double aggression of dust and mycobacterial infection.
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POLICARD, A., GERNEZ-RIEUX, C., TACQUET, A. et al. Influence of Pulmonary Dust Load on the Development of Experimental Infection by Mycobacterium kansasii. Nature 216, 177–178 (1967). https://doi.org/10.1038/216177a0
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DOI: https://doi.org/10.1038/216177a0
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