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Chlortetracycline and Mouse Intestinal Wall

Abstract

Chlortetracycline caused dramatic increases in intestinal weight of bacteria-laden and germ-free female mice only, the greatest in the former. Intestinal histamine and serotonin decreased in all mice except bacteria-laden females which showed increases in serotonin. Thus, sex and microbial status could be important in connexion with tetracycline intoxication.

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References

  1. Moser, R. H., Clin. Pharmacol. Therapeutics, 7, 117 (1966).

    Article  Google Scholar 

  2. Einheber, A., Rosen, H., Wren, R. E., and Beaudry, N. N., Biochem. Pharmacol., 15, 1093 (1966).

    Article  CAS  Google Scholar 

  3. Weissbach, H., Waalkes, T. P., and Udenfriend, S., J. Biol. Chem., 230, 865 (1958).

    CAS  PubMed  Google Scholar 

  4. Sullivan, T. J., Brit. J. Pharmacol., 16, 90 (1961).

    CAS  PubMed  Google Scholar 

  5. Hierowski, M., Proc. U.S. Nat. Acad. Sci., 53, 594 (1965).

    Article  ADS  CAS  Google Scholar 

  6. Yeh, S. D. J., and Shils, M. E., Proc. Soc. Exp. Biol. and Med., 121, 729 (1966).

    Article  CAS  Google Scholar 

  7. Fell, B. F., Smith, K. A., and Campbell, R. M., J. Path. Bact., 85, 179 (1963).

    Article  CAS  Google Scholar 

  8. Campbell, R. M., and Fell, B. F., J. Physiol., 171, 90 (1964).

    Article  CAS  Google Scholar 

  9. Biskind, M. S., and Biskind, G. R., Endocrinology, 32, 97 (1943).

    Article  CAS  Google Scholar 

  10. Grayhack, J. T., and Scott, W. W., Endocrinology, 48, 453 (1951).

    Article  CAS  Google Scholar 

  11. Gordon, H. A., and Bruckner-Kardoss, E., Amer. J. Physiol., 201, 175 (1961).

    CAS  PubMed  Google Scholar 

  12. Abrams, G. P., Bauer, H., and Sprinz, H., Lab. Invest., 12, 355 (1963).

    CAS  PubMed  Google Scholar 

  13. Lesher, S., Walburg, H. E., and Sacher, G. A., Nature, 202, 884 (1964).

    Article  ADS  CAS  Google Scholar 

  14. Jervis, H. R., and Biggers, D. C., Anat. Record, 148, 591 (1964).

    Article  CAS  Google Scholar 

  15. Shils, M. E., Clin. Pharmacol. Therapeutics, 3, 321 (1962).

    Article  CAS  Google Scholar 

Download references

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ROSEN, H., EINHEBER, A., BROWN, N. et al. Chlortetracycline and Mouse Intestinal Wall. Nature 214, 671–674 (1967). https://doi.org/10.1038/214671a0

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