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Fibrinogen and Adenosine Diphosphate-induced Aggregation of Platelets

Abstract

WHEN adenosine diphosphate (ADP) is added to plasma, aggregation of the platelets occurs1. This aggregation by ADP requires calcium2. A recent report indicated that in order for calcium and ADP to cause aggregation an additional component of plasma might be required2.

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References

  1. Gaarder, A., Jonsen, J., Laland, S., Hellem, A., and Owren, P. A., Nature, 192, 531 (1961).

    Article  ADS  CAS  Google Scholar 

  2. Born, G. V. R., and Cross, M. J., J. Physiol., 168, 41P (1963).

    Article  Google Scholar 

  3. Brinkhous, K. M., LeRoy, E. C., Cornell, W. P., Brown, R. C., Hazlehurst, J. L., and Vennart, G. P., Proc. Soc. Exp. Biol. Med., 98, 379 (1958).

    Article  CAS  Google Scholar 

  4. Born, G. V. R., and Cross, M. J., J. Physiol., 168, 178 (1963).

    Article  CAS  Google Scholar 

  5. Maxwell, R. E., Nickel, V. S., and Lewandowski, V., Biochem. Biophys. Res. Comm., 7, 50 (1962).

    Article  CAS  Google Scholar 

  6. Shermer, R. W., Mason, R. G., Wagner, R. H., and Brinkhous, K. M., J. Exp. Med., 114, 905 (1961).

    Article  CAS  Google Scholar 

  7. Ware, A. G., Fahey, J. L., and Seegers, W. H., Amer. J. Physiol., 154, 140 (1948).

    CAS  PubMed  Google Scholar 

  8. Schmid, H. J., Jackson, D. P., and Conley, C. L., J. Clin. Invest., 41, 543 (1962).

    Article  CAS  Google Scholar 

  9. Gokcen, M., and Yunis, E., Nature, 200, 590 (1963).

    Article  ADS  CAS  Google Scholar 

  10. Kaser-Glanzmann, R., and Luscher, E., Thromb. Diath. Haem., 7, 480 (1962).

    Article  CAS  Google Scholar 

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McLEAN, J., MAXWELL, R. & HERTLER, D. Fibrinogen and Adenosine Diphosphate-induced Aggregation of Platelets. Nature 202, 605–606 (1964). https://doi.org/10.1038/202605a0

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