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  • Digitale Medien  (154)
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  • Digitale Medien  (154)
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  • 2010-2014
  • 2005-2009
  • 2000-2004  (154)
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  • 101
    ISSN: 1573-2649
    Schlagwort(e): Health status ; Mode of administration ; Parkinson's disease ; Psychometrics ; Quality of life
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract This study evaluated the feasibility and psychometric properties of self-completed and telephone interview versions of a patient health-related quality-of-life (HQL) questionnaire for Parkinson's disease that included the SF-36 Health Survey (SF-36), the Parkinson's Disease Questionnaire (PDQ-39), and the Medical Outcomes Study Sexual Function Survey. Parkinson's disease patients (n = 150) completed the questionnaire twice: once at the study site and once over the telephone in a randomized order. Ninety-four percent of enrolled patients completed the first HQL assessment and 88% completed both assessments. Cronbach's α exceeded 0.70 for all scales except for the self-completed PDQ-39 Social Support subscale (0.57) and the telephone interview PDQ-39 Social Support (0.60) and Cognitions (0.67) subscales and the SF-36 General Health (0.60) and Social Function (0.61) subscales. There were no statistically significant differences in mean HQL scale scores across the two modes of administration. Mean scores for 3 of the PDQ-39 subscales and the Summary Index were significantly poorer (p 〈 0.05) for patients at later clinical stages. Similarly, patients with dyskinesias reported significantly poorer scores for 4 of the PDQ-39 subscales and the Summary Index and patients with self-reported comorbidities reported poorer SF-36 Physical Function and General Health subscale scores than patients without dyskinesias and comorbidities, respectively. This study suggests that the self-completed and telephone interview versions of the patient HQL questionnaire are feasible and valid for future clinical trial applications.
    Materialart: Digitale Medien
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  • 102
    Digitale Medien
    Digitale Medien
    Springer
    Quality of life research 9 (2000), S. 65-73 
    ISSN: 1573-2649
    Schlagwort(e): Cancer patients ; EORTC QLQ-C30 ; Longitudinal assessments ; Prognosis groups ; Quality of life
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The present study examines differences in quality of life between two points in time in a heterogeneous sample of cancer patients with different prognoses. The original sample comprised 253 patients, while the follow-up data obtained 3–4 years later included 75 patients, that is, 92% of the survivors. All the patients completed a questionnaire including the EORTC QLQ-C30. The research questions focus on overall changes in quality of life, and whether patients with a good prognosis would show less negative changes in quality of life than patients with a poor prognosis. The overall observed changes in quality of life were surprisingly small over a 3–4 year period. This study shows that prognoses do predict changes in social functioning and in some physical aspects of quality of life over a 3–4 year period after the assessment of prognoses by physicians. Prognoses did not, however, predict changes in psychological aspects of quality of life.
    Materialart: Digitale Medien
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  • 103
    ISSN: 1573-2649
    Schlagwort(e): Bladder cancer ; Cystectomy ; Postoperative adjustment ; Prospective study ; Quality of life
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract This study reports the changes in the quality of life (QoL) of 44 patients observed prospectively from pre-surgery to one year post-surgery. Two kinds of surgeries were compared: continent and incontinent urinary diversion. In most areas the QoL returned to the prior level within one year after surgery. However, patients were restricted in their physical activity, sexual activity, and emotional well-being. Using individual weights for different aspects of life (Fragen zur Lebenszufriedenheit – Module FLZM), QoL was higher than when using an unweighted measurement (Short Form 36, MOS). Two trends for the different developments in the QoL were established: general life satisfaction and social functioning tended to improve after a continent diversion but decreased after an incontinent diversion. The perceived global satisfaction with both kinds of diversion was high – 75% of the patients would choose the same kind of diversion again.
    Materialart: Digitale Medien
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  • 104
    ISSN: 1573-2649
    Schlagwort(e): Cancer ; Co-operative group ; Health economics ; Randomized controlled clinical trials ; Quality of life
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Background: Co-operative groups have played an important role in the advance of health-related quality of life (HRQL) research. However, definitions of the concept, criteria for selection of existing instruments and methods for data collection and interpretation remain poorly defined in the literature. A survey was conducted amongst the major cancer co-operative groups in order to gain a better understanding of their current policy and processes to ensure optimal HRQL data collection within cancer clinical trials. The topic of health economics was similarly addressed. Methods: A written questionnaire was addressed to 16 major European and North American cancer co-operative groups. Eleven groups responded (response rate: 69%), however, one group could not provide information for the survey, thus ten questionnaires were available for analysis. Results: The results from this survey among co-operative groups show that HRQL (more than health economics) is recognized as an important, although usually secondary, outcome measure in oncology trials. On the whole, co-operative groups have a rather flexible policy towards the inclusion of HRQL (and HE) into their clinical trials, and practice is very much on a case-by-case basis, but use standard practice guidelines and internal procedures is to ensure well-defined study protocols and enhance good quality studies.
    Materialart: Digitale Medien
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  • 105
    ISSN: 1573-2649
    Schlagwort(e): Cancer ; Content analysis ; Quality of life
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Although the subjective nature of quality of life is generally accepted, less attention has been paid to the procedure of selecting domains to be explored with questionnaires. To explore what contributes to cancer patients' quality of life, a survey was conducted with the aim of identifying contents of quality of life using cancer patients as `experts'. A questionnaire with open-ended items aimed at exploring the meaning of quality of life and at determining the contents of health and not health related quality of life, was submitted to a sample of cancer patients stratified by residence, cancer site and stage of disease. The 248 questionnaires received were transcribed and broken down into phrases to allow coding. A content analysis was performed, using as a conceptual framework, the domains identified by the Italian Society of Psycho-Oncology. Overall, 43 domains and a list of symptoms were identified. The two most frequently reported symptoms were pain (21.4% patients) and fatigue (14.1% patients). Social relationships and psychological domains were heavily represented. Twenty sub-domains related to the domain `psychological well-being'. This study suggests that information on the content of quality of life questionnaires to be submitted to people affected by a specific disease, should be derived by studying people suffering the specific disease. These results reinforce the criticism that available quality of life instruments are more likely to reflect the perspective of health professionals than patients.
    Materialart: Digitale Medien
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  • 106
    Digitale Medien
    Digitale Medien
    Springer
    Quality of life research 9 (2000), S. 161-176 
    ISSN: 1573-2649
    Schlagwort(e): Colonic diseases ; Functional ; Quality of life ; Questionnaires
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Irritable Bowel Syndrome (IBS) is a chronic recurring disorder with variable illness episodes that may continue for many years. Diagnosis is based on symptoms such as abdominal pain and irregular bowel habits. These symptoms, plus the influence of psychological factors and extraintestinal symptoms, adversely affect the health-related quality of life (HRQoL) of individuals with IBS. This paper summarizes publications relating to the characteristics of IBS and associated HRQoL. Significantly lower scores on both the physical and mental health scales of the Short Form-36 are reported for individuals with IBS symptoms as compared with asymptomatic controls and US norms. IBS negatively affects general health, vitality, social functioning, bodily pain, diet, sexual function, sleep, and is associated with lost time from work. IBS-specific instruments that incorporate many of these domains have recently become available. HRQoL appears to correlate with IBS symptom severity and influences decisions to seek medical care. Psychosocial problems are also linked with IBS in relation to health care utilization. However, the full burden of this painful illness is still unknown since only 25–60% of individuals suffering from IBS symptoms see a physician for their illness.
    Materialart: Digitale Medien
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  • 107
    Digitale Medien
    Digitale Medien
    Springer
    Quality of life research 9 (2000), S. 579-586 
    ISSN: 1573-2649
    Schlagwort(e): Bipolar disorder ; Health status ; Mental health ; Outcome assessment (health care) ; Quality of life
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Background: Despite a growing number of studies of patients' health values (utilities), little is known about health values of patients with mental illness, particularly bipolar (manic-depressive) disorder. Methods: We administered a computerized rating scale, time tradeoff, and standard gamble to 53 patients. Patients were asked to rate or value their current state of health overall and then their current mental health. In addition, we administered the SF-36; Inventory of Depressive Symptoms (IDS-C); Positive and Negative Syndrome Scale (PANSS); Young Mania Rating Scale (YMRS); and Global Assessment of Functioning Scale. Results: The patients' median (25th, 75th percentile) age was 43 (37, 50); 62% were female. Mean (±SD) health ratings for current overall health were 68.0 (±20.3) vs. 61.0 (±25.7) for current mental health (p-value for difference = 0.02). On the time tradeoff, scores for current overall health averaged 0.71 (±0.37) vs. 0.61 (±0.39) for current mental health (p = 0.02); on the standard gamble, mean scores were 0.77 (±0.32) for current overall health vs. 0.70 (±0.35) for current mental health (p = 0.11). In univariate analyses, rating scale, time-tradeoff, and standard gamble scores for both current overall health and for current mental health were correlated with the SF-36 and all psychiatric scales (|r| = 0.22–0.76) except the YMRS (|r| ≤ 0.13). In multivariable analyses, health values for current overall health were related to factors different from those that were related to health values for current mental health (R 2 = 0.38–0.65), and none of the health value measures was related to the YMRS. Conclusion: Health values of patients with bipolar disorder are higher for their current health overall than for their current state of mental health. Health values are related to certain health status attributes and to level of depression but perhaps not to level of mania.
    Materialart: Digitale Medien
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  • 108
    ISSN: 1573-2649
    Schlagwort(e): Asthma ; Child report ; Parent report ; Quality of life
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract This study compares the reproducibility, construct validity and responsiveness of self-report and parent-report quality of life questionnaires How Are You (HAY) for 8–12-year-old children with asthma. A total of 228 Dutch children with asthma and their parents completed the HAY and daily recorded the child's asthma symptoms in a diary. Additionally 296 age- and -gender matched healthy children and their parents completed the generic part of the HAY. Reproducibility and responsiveness were examined in a sub-group of 80 children with asthma. In this group, three measurements were carried out, at baseline, after one week and once during the following 6 month when the clinical asthma status had changed. The within-subject standard deviations (SD) of three dimensions (physical activities, social activities, self-management) differed significantly (p 〈 0.05) in favour of the parent-version, indicating that the reproducibility of the parent version was better than that of the child version. The mean score-differences between children with asthma and healthy children as reported by parents did not significantly differ from those reported by children, except for cognitive activities (e.g. be able to concentrate on school work). The mean differences with regard to children with a different actual asthma status (symptom analysis), as reported by both informants, did not differ. Compared to the child-version, the parent-version showed greater ability to detect changes in children's quality of life over time for all but one dimension, indicating better responsiveness. The results indicate that in discriminative studies child and parents reports can be substituted on a group-level. In longitudinal studies data have to be obtained from parents. Consequently, caregivers collecting quality of life data for longitudinal purposes in daily practice should collect these data simply from parents.
    Materialart: Digitale Medien
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  • 109
    ISSN: 1573-2649
    Schlagwort(e): Ambulatory care ; Cancer pain ; Psychological assessment ; Quality of life
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Because cancer pain can in many cases be intermittent, the presence or absence of pain in ambulatory care patients on any given clinic visit may not be an accurate characterization of the impact of pain on functioning or health-related quality of life (HRQOL). The purpose of this study was to describe the relationship between temporal aspects of pain presentation and HRQOL among 187 stage III/IV cancer patients using the Brief Pain Inventory and the EORTC QLQ-C30. A total of 43% of patients reported pain the previous week, with 22% reporting no pain at the time of assessment. Differences between three pain groups (No Pain, Past Pain, and Current Pain) were significant for global HRQOL and five dimensions of HRQOL. Severity of pain was also associated with each dimension of HRQOL. This study highlights the complex relationship between pain presentation and HRQOL. The findings support the continuing need for detailed pain assessments among cancer patients treated in ambulatory care settings. Specifically, standardized, self-report measures of cancer pain that include ‘frequency’ as well as severity may be the most accurate approach to capture the impact of pain on HRQOL.
    Materialart: Digitale Medien
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  • 110
    Digitale Medien
    Digitale Medien
    Springer
    Quality of life research 9 (2000), S. 931-940 
    ISSN: 1573-2649
    Schlagwort(e): HIV/AIDS ; Measurement ; Quality of life ; Women
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Although women had been under recognized in the literature on HIV/AIDS, increasing numbers of studies have focused on the lives and experiences of women living with HIV/AIDS. Areas of research in which the study of women and HIV continues to be noticeably lacking include health related quality of life (HRQOL). This paper describes HRQOL in an inner city sample of 287 HIV positive non-pregnant women, interviewed as part of a larger multi-site CDC funded study of the reproductive health of women. The average age of the respondents was 33 years and women had known their HIV status an average of 41 months. HRQOL was assessed using a 17-item modified version of the Medical Outcomes Study-HIV Health Survey and demonstrated acceptable internal consistency (0.64-0.89) and variability. Women in our study were similar to other HIV-positive female samples and reported lower levels of well-being and functioning than some HIV-positive male samples. Women's responses to individual items and areas of potential need for health care are discussed. Examination of HRQOL in women with HIV can aid in the comparison of how women and men are affected by HIV and can help health care professionals identify needed services and include possible interventions to promote quality of life.
    Materialart: Digitale Medien
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  • 111
    Digitale Medien
    Digitale Medien
    Springer
    Quality of life research 9 (2000), S. 129-137 
    ISSN: 1573-2649
    Schlagwort(e): EORTC QLQ-C30 ; Gynecological cancer ; Psychometric property ; Quality of life ; Standard Chinese
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The majority of quality of life (QOL) questionnaires have been developed and used in English-speaking or Western European countries. The aims of this study were to provide the Standard Chinese version of the European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire (EORTC QLQ-C30 version 2.0), and evaluate its psychometric properties. The translation process included independent translation, back translation, a pilot test with gynecological cancer patients, and a review and approval by the original developers. Participants in the major study included gestational trophoblastic disease patients (n = 68), ovarian cancer patients (n = 105), and other types of gynecological cancer patients (n = 18). The average completion time of the Standard Chinese version was 8.1 ± 2.9 min. All item-subscale correlation coefficients exceeded the criterion of item-convergent validity (r 〉 0.40) except item 1, 5, 20, and 25, and all items correlated significantly higher with their own subscale than with other subscales except item 1, 20, and 25. The correlation coefficients among all subscales were significant but modest (r = 0.40–0.70). Seven out of nine subscales met the minimal standards of reliability (Cronbach's α 〉 0.70). In conclusion, the Standard Chinese version of the EORTC QLQ-C30 is a valid instrument overall in assessing the QOL of Chinese gynecological cancer patients.
    Materialart: Digitale Medien
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  • 112
    ISSN: 1573-2649
    Schlagwort(e): Proxy measures ; Quality of life ; Surrogacy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract In studies of the effect of cancer treatment in the advanced disease setting, researchers have attempted to avoid missing data for quality of life (QOL) assessments by either substituting proxy for patient assessments from the outset or by interspersing proxy measures when patients are unable to respond. Although poor agreement between patient and proxy assessments has been amply demonstrated in the literature, interest in using proxy measures persists. Completion of the Spitzer QL-Index by a small sample of patients with brain metastases and family member proxies provided data for evaluating the ability to substitute proxy for patient QOL assessments. These data cannot address treatment efficacy due to the modest sample size. Rather, the analyses serve to alert researchers to the important distinction (in a clinical trial setting) between agreement and the use of the proxy as a surrogate. We present several methods for evaluating the accuracy of proxy measures and for identifying other sources of error and bias that may vary with time or with treatment arm. Lin's concordance correlation coefficient suggests that proxies are generally a poor substitute for capturing a patient's perspective of his/her QOL. A longitudinal analysis suggests that the use of proxy rather than patient responses could lead to different conclusions concerning radiation therapy's effect on QOL.
    Materialart: Digitale Medien
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  • 113
    Digitale Medien
    Digitale Medien
    Springer
    Quality of life research 9 (2000), S. 207-218 
    ISSN: 1573-2649
    Schlagwort(e): Diabetes ; DTSQ ; LQD ; Non-insulin-dependent diabetes ; Quality of life
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The purpose of the study was to find out which of five Quality of life (QoL) questionnaires are reliable and valid for evaluating the QoL in German patients with type 2 diabetes: the Diabetes Treatment Satisfaction Questionnaire (DTSQ), the Well-Being Questionnaire (WBQ), the Short Form SF36 of the Medical Outcome Study (SF36), the Diabetes39 and the Quality of Life with Diabetes (LQD) questionnaire. A stratified sample of 144 patients who were attending one of nine special hospitals for people with diabetes at the time of the study were given the questionnaires twice. Most of the scales of the questionnaires had internal consistencies (α) of above 0.80 as recommended; the retest reliabilities were lower, especially for scales evaluating satisfaction with levels of blood sugar and treatment in general. A factor analysis of all scale scores yielded four factors: (1) physical aspects, (2) well-being and satisfaction, (3) diabetes-specific stress, and (4) treatment satisfaction. Construct validity showed frequency of hypoglycemias, neuropathies, treatment with insulin and number of late complications to have a negative impact on QoL scores. No single questionnaire covered all relevant aspects of the QoL of subjects with type 2 diabetes. Thus, quality of life in diabetic people should be evaluated with scales representing the cognitive dimensions found in this study so as not to miss significant aspects.
    Materialart: Digitale Medien
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  • 114
    ISSN: 1573-2649
    Schlagwort(e): Coronary artery bypass grafting (CABG) ; Ejection fraction ; Quality of life
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Aim: To describe the relief of symptoms and improvement in Quality of Life (QoL) 5 years after coronary artery bypass grafting (CABG) in relation to preoperative ejection fraction (EF). Methods: Patients who underwent CABG between 1988 and 1991 in western Sweden were approached with an inquiry prior to surgery and 5 years after the operation. Quality of Life was estimated with three different instruments: Physical activity score, Nottingham Health Profile and Psychological General Well-being Index. Results: Among all patients who underwent CABG (n = 1904) the 5-year mortality rate was 27% in those with EF 〈 0.40 and 12% in those with EF ≥ 0.40 (p 〈 0.0001). In all, 849 patients, of whom 58 (7%) had EF 〈 0.40 participated in the evaluation. Neither physical activity, symptoms of chest pain, dyspnea nor any indices of QoL were significantly associated with preoperative EF. Improvement in physical activity, symptoms of chest pain and dyspnea and various estimates of QoL appeared similar and marked regardless of preoperative EF. Conclusion: Among survivors there was no association between preoperative EF and symptoms or various estimates of QoL 5 years after CABG. Improvement in symptoms and QoL were not dependent on preoperative EF.
    Materialart: Digitale Medien
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  • 115
    ISSN: 1573-2649
    Schlagwort(e): Captopril ; Heart failure ; Losartan ; Missing data ; Quality of life
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Objective: To measure health-related quality-of-life (HRQoL) in elderly symptomatic heart failure patients following treatment with an angiotensin II receptor antagonist (losartan) vs. an angiotensin-converting-enzyme (ACE) inhibitor (captopril). Methods: Patients (age ≥65 years) were randomised to losartan, titrated to 50 mg once daily, or captopril, titrated to 50 mg three times daily, as tolerated. Sickness Impact Profile (SIP) and Minnesota Living with Heart Failure (LIhFE) questionnaires were administered at baseline, weeks 12 and 48. Composite hypothesis testing of change in HRQoL from baseline for completers, and withdrawal for unfavourable events (death, clinical/laboratory adverse experience) was used to account for differential dropout rates. Results: In 203 patients completing the substudy (week 48), significant and comparable improvements in HRQoL from baseline were observed for both treatment groups (p ≤ 0.001). Although there was a trend favouring losartan vs. captopril for the composite HRQoL endpoint (unadjusted p = 0.018, one-sided), this was not considered significant after adjusting for multiple testing. Significantly more captopril patients in the substudy subset withdrew for unfavourable reasons (19.6 vs. 10.9%, p = 0.038). Conclusions: Significant improvements in HRQoL were observed in elderly patients with symptomatic heart failure treated with losartan and captopril long-term. A trend favouring losartan in the composite measure of drug tolerability/quality of life was not significant, but losartan was generally better tolerated than captopril in that significantly fewer losartan patients discontinued therapy.
    Materialart: Digitale Medien
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  • 116
    ISSN: 1573-2649
    Schlagwort(e): Coping style ; Personality ; Quality of life ; Statistical-modelling
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Objective: To determine the role of health status, personality and coping style, on self-report health-related quality of life (QoL). Methods: Participants were HIV seropositive individuals at all disease stages from three samples (a) gay/bisexual men from the UK, (b) injecting drug users from the UK, (c) injecting drug users from Italy. All participants completed questionnaires evaluating QoL, personality, coping style and social support. Explicit models of the relationships between the measured variables based on a review of the literature were tested using structural equation modelling. Results: Health status was modestly associated with the physical but not the psychological aspects of QoL (β = 0.44). Neuroticism was strongly associated with psychological QoL (β = −0.73) but only weakly with physical QoL (β = −0.21). The samples did not differ in either the pattern or the magnitude of these relationships. Mediating factors such as coping style, social support and other personality variables had only a weak influence on the role of Neuroticism. Conclusions: Neuroticism had a strong influence on health-related QoL that was independent of health status. Neuroticism was more strongly associated with the psychological aspects of QoL than health status. Coping styles and the other psychological variables assessed had only a weak mediating influence on this relationship.
    Materialart: Digitale Medien
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  • 117
    ISSN: 1573-2649
    Schlagwort(e): Factor analysis ; Germany ; New Zealand ; Oral health ; Poland ; Quality of life ; Reliability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract A questionnaire designed to measure oral health-related quality of life (OHRQOL) in adults and children was assessed for its factorial structure and reliability using data from the Second International Collaborative Study on Oral Health Outcomes in New Zealand, Poland and Germany. Principal component analysis with orthogonal and oblique rotation was applied. The three-factor structure hypothesized for the children's questionnaire (self-reported oral disease symptoms, perceived oral well-being, social and physical functioning) was confirmed in New Zealand and Poland, and two self-reported oral disease symptom dimensions emerged in Germany. Five factors instead of the three hypothesized were identified for adults: two dimensions of symptoms were identified, and social and physical functioning appeared to be independent dimensions of OHRQOL. Similarity between the factors was demonstrated in all three countries. The reliability of the questionnaire ranged from moderate to excellent depending on the dimension and the country. These findings provide preliminary evidence of the cross-cultural stability of the OHRQOL questionnaire in New Zealand, Poland and Germany, for both children and adults. Further investigations by the present authors of the properties of the instrument in other samples will focus on demonstrating the stability and replicability of the factor structure identified here.
    Materialart: Digitale Medien
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  • 118
    ISSN: 1573-2649
    Schlagwort(e): Chronic bronchitis ; EuroQoL (EQ-5D) ; Health outcomes ; Medical outcomes study 6-item general health survey (MOS-6A) ; Measure yourself medical out come profile (MYMOP) ; Quality of life
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract There is little published information on the measurement of health status or quality of life in acute exacerbations of chronic bronchitis. The measure yourself medical outcome profile (MYMOP), the medical outcomes study 6-item general health survey (MOS-6A), and EuroQoL (EQ-5D) were evaluated in 81 patients with acute exacerbations of Type-1 chronic bronchitis presenting at a single general practice centre in Glasgow. The questionnaires were administered at the first clinic visit and at a second visit within 1 week of treatment completion. Item scores for MYMOP were generally more responsive than those for the other instruments, as assessed by standardised response means and an index of responsiveness for those patients reporting minimal change between visits. Construct validity was demonstrated for the MYMOP by the gradient in score change with the patient's perceived change in clinical condition and by the relationship between score change and the physician's assessment of clinical outcome. This study demonstrated that the MYMOP is a valid and potentially useful instrument for the assessment of patient outcomes in acute exacerbations of chronic bronchitis and is more responsive than the MOS-6A or EQ-5D in this setting. The choice of instrument will vary according to the objective of the study.
    Materialart: Digitale Medien
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  • 119
    Digitale Medien
    Digitale Medien
    Springer
    Quality of life research 9 (2000), S. 1041-1052 
    ISSN: 1573-2649
    Schlagwort(e): Cancer ; Proxy ; Quality of life
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The objective of the study was to determine possible differences in perception of quality of life (QoL) between patients with metastatic breast or prostate cancer, their partners, and the treating physician. Patients with metastatic breast cancer (n = 71), and metastatic prostate cancer (n = 29), a partner, and the physician each completed the same QoL questionnaire indicating how they perceived the patient's QoL. The European organization for research and treatment of cancer (EORTC) QLQ-C30 questionnaire was used to assess patients with breast cancer and the modified prostate cancer specific quality of life instrument (PROSQOLI) for patients with prostate cancer. There was reasonable agreement in mean scores between patients, and physicians or partners, for many domains of QoL; however, there was substantial discordance between scores when considering individual patients. For patients with metastatic breast cancer, physicians systematically underestimated overall QoL (p = 0.0002), social functioning (p = 0.001), and role functioning (p = 0.008), while partners showed better agreement. With prostate cancer physicians tended to underestimate pain, while mean scores for spouses were more concordant. There is substantial variability between ratings of QoL by physicians or partners, as compared to patient ratings. Medical decisions should be based on information about QoL provided by patients using validated methods.
    Materialart: Digitale Medien
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  • 120
    Digitale Medien
    Digitale Medien
    Springer
    Quality of life research 9 (2000), S. 1005-1013 
    ISSN: 1573-2649
    Schlagwort(e): Elderly patient ; Primary carer ; Quality of life ; Quality of planning for discharge
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Discharge planning endeavours to assist the transition of patients from the acute hospital setting into the community. We examined the quality of discharge planning from the perspective of the carer. Spouses were the most common carers for the elderly patients in our study. Many carers were also elderly, with their own health problems. Using a new instrument (entitled PREPARED) (K. Grimmer and J. Moss, Int J Qual Health Care (in press)), carers rated the quality of planning for discharge much lower than did the patient, indicating that their needs were often not met when discharge was being planned. In free text responses, carers expressed their dissatisfaction over communication about how the family would cope once the patient went home. Carers generally had lower summary mental quality of life scores than the Australian norms (as measured by the SF-36 health survey (J. Ware and R. Sherbourne, Med Care 1992; 30: 473–483)), suggesting that the caring role may have impacted upon their emotional wellbeing. The rate of use of community services in the first week post-discharge was low, suggesting that carers and patients carried the majority of the burden immediately after discharge. We suggest that planning for hospital discharge requires more consideration of the carer.
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  • 121
    Digitale Medien
    Digitale Medien
    Springer
    Quality of life research 9 (2000), S. 755-761 
    ISSN: 1573-2649
    Schlagwort(e): Disability ; Exercise ; Osteoporosis ; Quality of life ; Spinal fractures
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract There continues to be a lack of consensus on the meaning and definition of the concept of quality of life. An implicit distinction for many measures of quality of life is from measures of health status based upon the presence of disability in functional domains. A further assumption in many scales is that quality of life is a unitary construct. The Osteoporosis Functional Disability Questionnaire (OFDQ) assessed some domains of function but is not unidimensional. It was developed to evaluate the progress and outcome of a structured exercise program for people with spinal compression fractures due to osteoporosis. The OFDQ assesses five domains relevant to the pain and disability in this population: pain, depression, function in performing common daily activities, socialization, and confidence in the exercise program. Longitudinal data from three cases are used to illustrate the utility of this multidimensional approach in evaluating the outcome of exercise treatment and understanding important aspects of the subjective life of people with osteoporosis.
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  • 122
    ISSN: 1573-2649
    Schlagwort(e): Anorexia/cachexia ; Quality of life ; Scale validation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Purpose: The original Functional Assessment of Anorexia/Cachexia Therapy (FAACT) was designed to measure general aspects of quality of life (QOL) as well as specific anorexia/cachexia-related concerns. Our primary purpose was to reduce the number of anorexia/cachexia subscale items in a manner that either retains or improves reliability, validity and precision. Methods: The FAACT was administered using an interactive computer program that allowed immediate entry of the data. A total of 213 patients were recruited. Results: A combined empirical and conceptual approach led to the reduction of the anorexia/cachexia subscale (A/CS) from 18 to 12 items. A 26-item trial outcome index (TOI) combining physical well-being (PWB), functional well-being (FWB), and the A/CS-12 was highly reliable and sensitive to change in performance status rating (PSR). We found that PWB, FWB, and A/CS-12 subscales performed differently. Specifically, PWB and FWB scores decreased in patients whose (PSR) worsened. However, although A/CS-12 scores were responsive to change in PSR over time, average A/CS-12 scores of all patients, even those whose PSR worsened, improved over the course of treatment. Conclusions: Elimination of six items from the anorexia/cachexia subscale of the FAACT was accomplished without loss of internal consistency or sensitivity to change in performance status. The A/CS-12 subscale provides unique, important information not captured by a generic chronic illness questionnaire.
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  • 123
    Digitale Medien
    Digitale Medien
    Springer
    Quality of life research 9 (2000), S. 617-623 
    ISSN: 1573-2649
    Schlagwort(e): Children ; Population sample ; Quality of life
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract This study aimed to assess the quality of life of a population sample of schoolchildren. The Generic Children's Quality of Life Measure (GCQ) has been developed to allow comparison between chronically ill children and the general child population. The measure assesses how the child views his or her life and also how they would like it to be. Quality of life is measured as the discrepancy between the two viewpoints. This large community-based survey aimed to establish GCQ norm values for children aged 6–14 years. The children were from a sample of schools stratified by geographical location and social need: rural affluent, rural low affluence, urban affluent and urban low affluence. 720 completed questionnaires were analysed. The scores were normally distributed with a wide range. The GCQ showed an acceptable reliability with a Cronbach's α of 0.75. The quality of life score was not correlated with age (r = −0.02, p = 0.64) nor with the deprivation score of the area in which the children lived (r = −0.026, p = 0.49). There were no significant differences between the scores by gender (p = 0.22) nor by rural/urban location (p = 0.60). Normative values were established. The GCQ is suitable for using with children over a large age range (6–14 years) without the scores being confounded by the age, gender, affluence or geographical location.
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  • 124
    ISSN: 1573-2649
    Schlagwort(e): Quality of life ; Radiotherapy ; Response shift
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract In medicine, response shift refers to a change — as a result of an event such as a therapy — in the meaning of one's self-evaluation of quality of life. Due to response shift, estimates of side effects of radiotherapy may be attenuated if patients adapt to treatment toxicities. The purpose of our study was to assess to what extent two components of response shift, scale recalibration and changes in values, occur in early-stage breast cancer patients undergoing radiotherapy and to examine what the implications would be for treatment evaluation. In the week before start of post-operative radiotherapy, 46 patients filled out a questionnaire consisting of quality of life items of the SF-36 and the Rotterdam symptom checklist (RSCL) (pretest). During radiotherapy, patients were asked to fill out the questionnaire twice: a posttest (quality of life at that moment) and a thentest (quality of life before treatment, retrospectively), supposedly using the same internal standard. Changes in values were studied by asking the patients on the two occasions to rate the importance of seven attributes representing various domains of quality of life. Patients were also asked whether their quality of life with respect to the measured aspects had changed since the pretest (subjective transition scores). Significant scale recalibration effects were observed in the areas of fatigue and overall quality of life. When the groups were divided according to their subjective transition scores, significant scale recalibration effects were found in case of worsened quality of life for fatigue and overall quality of life, and in case of improved quality of life for fatigue and psychological well-being. The mean importance ratings remained fairly stable over time, except for ‘skin reactions’, which obtained less importance at the end of radiotherapy than before. In conclusion, effects of scale recalibration were observed that would have significantly affected quality of life evaluations, in that the impact of radiotherapy on fatigue and overall quality of life would have been underestimated. Changes in internal values were observed only for ‘skin reactions’.
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  • 125
    ISSN: 1573-2649
    Schlagwort(e): Asthma ; Chronic obstructive pulmonary disease ; Epilepsy ; Health-related quality of life ; Health status ; Ischemic coronary disease ; Quality of life ; Rheumatoid arthritis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The objective of this study was to compare the health-related quality of life (HRQL) of patients with epilepsy with populations suffering from different chronic diseases, using the short form 36 (SF-36) health profile measure. The populations to be compared were adult patients drawn from hospital based registers, with confirmed epilepsy (n = 397), angina pectoris (n = 785), rheumatoid arthritis (n = 1030), asthma (n = 117) and chronic obstructive pulmonary disease (COPD) (n = 221). Health-related quality of life scores were compared using analysis of covariance (ANCOVA) for predicting mean scores adjusted for age, gender, education and comorbidity. Patients with epilepsy on average scored highest on all scales, reflecting that in our sample the majority had well-controlled epilepsy. Our results indicate that the HRQL of a representative sample of patients with epilepsy is good, when compared with other chronic disorders, although reduced in several dimensions compared with a general reference population. Patients with rheumatoid arthritis (RA) and COPD scored lowest on the physical function scales, while rheumatoid arthritis patients reported most pain.
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  • 126
    Digitale Medien
    Digitale Medien
    Springer
    Quality of life research 9 (2000), S. 873-882 
    ISSN: 1573-2649
    Schlagwort(e): Asthma ; Quality of life ; Questionnaire ; Satisfaction ; Validation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The Patient Satisfaction with Asthma Medication (PSAM) questionnaire was developed because no treatment satisfaction questionnaire could be identified that was comprehensive yet brief enough for use in clinical trials. Adult moderate asthmatics residing in Canada using an inhaled medication (either salmeterol, formoterol, or albuterol) self-administered the questionnaire, which also included the Asthma Quality of Life Questionnaire (AQLQ). A total of 53 asthmatics (70% female, 45% married, mean age: 47 years) completed the questionnaire. Using variable clustering, four PSAM scales were identified: Inhaler Properties, Comparison with Other Medications, Overall Perception of Medication, and Relief. Internal-consistency reliability provided evidence of reliability and lack of redundancy (Cronbach's Alpha: 0.82–0.88). Test-retest reliability was acceptable (ICC values at or near 0.70). As expected, interscale PSAM correlations were moderate to high; correlations between the PSAM and the AQLQ were low to moderate. To assess known groups validity, respondents were categorized by self-reported degree of asthma control: ‘very well controlled’ ‘somewhat controlled’, and ‘not well controlled’. Significant between-groups differences were found on all PSAM scales except Inhaler Properties. Patients categorized as ‘very well controlled’ tended to report highest PSAM scale scores. The PSAM questionnaire demonstrated reliability and validity in moderate asthmatics. Responsiveness should be assessed in future, prospective studies.
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  • 127
    ISSN: 1573-2649
    Schlagwort(e): Diabetes mellitus ; Functional insulin treatment ; Lifestyle ; Quality of life ; Randomised cross-over study ; Treatment satisfaction
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Even a small improvement in satisfaction with treatment for a chronic disease can be valuable. However, sensitive measurements instruments are needed to assess the effects of treatment changes in patients already well satisfied with baseline treatment. Such instruments were thought to be necessary to deal with ceiling effects in scores of satisfaction with functional insulin treatment (FIT) accommodating full flexibility of food intake and lifestyle in diabetes by manipulation of insulin (FIT; Howorka etal. 2000). The Status(S) version of the Diabetes Treatment Satisfaction Questionnaire (DTSQ, Bradley 1994) was extended with items measuring specific components of FIT and its psychometric properties investigated in a validation study with 171 FIT patients with diabetes. A new Change(C) version of DTSQ extended for FIT was used together with the DTSQ(S) by 52 participants in a subsequent randomised cross-over study involving new fast-acting lispro vs. regular insulin, where treatment satisfaction was the primary outcome variable. Insulin lispro use improved satisfaction (p ≤ 0.001) both, on classical and extended versions of DTSQ(S) and (C), despite high baseline levels of satisfaction. However, the DTSQ(C) augmented the effects of lispro (p = 0.0001) apparent on DTSQ(S) scores and revealed significant treatment effects (p ≤ 0.01) not significant with DTSQ(S). In parallel, glycaemic control improved with lispro (e.g., HbA1c, p = 0.023). Improved satisfaction with treatment was more apparent with DTSQ(C) than DTSQ(S) in patients who at baseline were at or near ceiling for treatment satisfaction.
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  • 128
    Digitale Medien
    Digitale Medien
    Springer
    Quality of life research 9 (2000), S. 763-766 
    ISSN: 1573-2649
    Schlagwort(e): Osteoporosis ; Qualeffo ; Quality of life ; Vertebral fractures
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Vertebral fractures cause pain and may hamper activities of daily life, mobility, social activities and mental function. These aspects of quality of life may be assessed with a generic or disease-specific quality of life questionnaire. The International Osteoporosis Foundation has developed a specific questionnaire for patients with vertebral fractures. This questionnaire Qualeffo-41, contains 41 questions in the domains pain, physical function, social function, general health perception and mental function. The questionnaire has been translated into many languages. A multicenter validation study showed good repeatability, adequate internal consistency and good discrimination between patients with vertebral fractures and control subjects. Further clinical testing of Qualeffo-41 showed that the domain and total scores increased linearly with the number of prevalent vertebral fractures. Lumbar fractures had more impact on quality of life than thoracic fractures. The impact of vertebral fractures on quality of life increased with age. The results with Qualeffo-41 confirm the decreased quality of life in patients with vertebral fractures.
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  • 129
    ISSN: 1573-2649
    Schlagwort(e): Fluctuations ; Health state utilities ; Parkinson's disease ; Preference measurement ; Quality of life
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The purpose of this study was to derive patient preferences and utilities for outcomes associated with treatment of motor fluctuations, or ‘off-time’ for patients with Parkinson's disease (PD). Visual analog scale (VAS) and standard gamble (SG) approaches were used with 60 patients to determine patient preferences and utilities for 10 health state descriptions. Health state descriptions were categorized according to two factors: disease severity, and proportion of the day with ‘off-time’. There were two representative levels of disease severity, based on Hoehn and Yahr stages 1.5 and 2.5: unilateral disease with no postural instability, and bilateral disease with some postural instability. These severity levels were combined with five levels of ‘off-time’ per day ranging from none to 〉 75% of the day. Patients' mean preference or utility for their own current health ranged from 0.65 ± 0.20 (VAS) to 0.74 ± 0.22 (SG). Patients assigned the lowest mean values to the health state description for Hoehn and Yahr stage 2.5 with ‘off-time’ for 〉 75% of the day (VAS: 0.17 ± 0.17; SG: 0.49 ± 0.27). The highest mean values were assigned to Hoehn and Yahr stage 1.5 with no ‘off-time’ (VAS: 0.83 ± 0.17; SG: 0.85 ± 0.18). The results of this study indicated patients with PD would likely seek treatment that would minimize the amount of ‘off-time’ experienced per day, and that patients were relatively risk averse.
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  • 130
    Digitale Medien
    Digitale Medien
    Springer
    Digestive diseases and sciences 45 (2000), S. 359-365 
    ISSN: 1573-2568
    Schlagwort(e): functional liver blood flow ; splanchnic hemodynamics ; intrahepatic shunts ; kinetics ; kinetic models
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Sorbitol and indocyanine green (ICG) have high hepatic extraction fractions (E sorb and E ICG) in normal subjects. A curved relationship has been observed between E sorb and E ICG in liver disease. According to one interpretation, the decrease of E sorb is a result of intrahepatic shunting and 1 − E sorb is the fraction of shunted flow (the shunt hypothesis). Under the further assumption that capillarization of functioning sinusoids prevents hepatic uptake of plasma protein-bound ICG and allows uptake of water-soluble sorbitol, the difference Esorb − EICG has been suggested as a measure of capillarization. We propose an alternative hypothesis: that the sinusoidal permeability–surface area products for sorbitol and ICG are reduced in proportion by liver disease (proportional reduction hypothesis). Based on the sinusoidal perfusion model, predictions were produced from both hypotheses for the relation between E sorb and E ICG and the additional effects of capillarization were described. By use of liver vein catheterization, E sorb and E ICG were simultaneously measured during continuous infusions in 53 human subjects with varying degrees of liver disease. The data were in better agreement with the predictions of the proportional reduction hypothesis than with the shunt hypothesis. Even though both intrahepatic portosystemic shunts and sinusoidal capillarization are known to occur in cirrhosis and also may have influenced our data, they appeared to be of minor importance from a kinetic point of view. These findings favor the proportional reduction hypothesis and do not support the use of systemic nonrenal clearance of sorbitol as a measure of “functional liver blood flow.”
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  • 131
    Digitale Medien
    Digitale Medien
    Springer
    Water resources management 14 (2000), S. 417-434 
    ISSN: 1573-1650
    Schlagwort(e): adsorption ; feldspar ; industrial effluent ; pollution control ; kinetics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Architektur, Bauingenieurwesen, Vermessung , Geographie
    Notizen: Abstract Feldspar, among many natural substances such as termitemount-clay, saw-dust, kaolinite and dolomite, offers asignificant removal ability for sulfate, phosphate, and coloredsubstances. Optimization of experimental parameters such assolution pH and flow rate reveals, that the maximum efficiency forremoval of phosphate, sulfate, and colored substances is about42, 52, and 73% respectively. X-ray diffraction, adsorptionisotherm and recovery studies suggest, that the removal processof anions occurs via ion exchange in conjunction with surfaceadsorption. Furthermore, reaction rate studies indicate thatthe removal of the selected pollutants by feldspar follows first-order kinetics. Although the percent removal, under the optimized conditions, is higher for laboratory prepared solutions, efficiency is a little less for industrial effluentsdue to interferent effects.
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  • 132
    Digitale Medien
    Digitale Medien
    Springer
    Journal of thermal analysis and calorimetry 62 (2000), S. 353-363 
    ISSN: 1572-8943
    Schlagwort(e): controlled environment ; high-T c superconductors ; kinetics ; microgravimetric investigations
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract Many properties of oxide superconductors depend on the oxygen concentration and its distribution in the samples. The microgravimetric method is very useful to study of oxide superconductors, as it allows investigations in vacuum and controlled environments in classical applications: thermogravimetric analysis for the study of solid-state reactions, determinations of oxygen contents in redox reactions and the combined measurement of mass and additional parameters, e.g. evolved gas analysis etc. Single-phase samples of high-temperature superconductors were synthesized from stoichiometric mixtures of high-purity oxides and carbonates. Appropriate amounts of the precursor powders were homogenized manually or by a mechanical ball mill and subsequently calcined at temperatures in the 800 to 950°C range with intermediate grinding to ensure homogenous reaction. The lattice parameters of all preparations were controlled, in both initial and final experiments, by the X-ray powder method (CuKα radiation), using a Stadi P (Stoe) diffractometer with a position-sensitive detector. It is well known that temperature and mass can be measured with an accuracy higher by orders of magnitude than it is still possible for the thermoanalyst to determine the transformation temperatures or the mass changes due to overlapping partial reactions. Applications of Cahn microbalance to study of high-temperature superconductors are presented.
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  • 133
    Digitale Medien
    Digitale Medien
    Springer
    Journal of thermal analysis and calorimetry 62 (2000), S. 747-755 
    ISSN: 1572-8943
    Schlagwort(e): benzoic acid ; europium complex ; kinetics ; non-isothermal ; thermal decomposition
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract The thermal decomposition of Eu2(BA)6(bipy)2 (BA=C2H5N– 2, benzoate; bipy=C10H8N2, 2,2'-bipyridine)and its kinetics were studied under the non-isothermal condition by TG-DTG, IR and SEM methods. The kinetic parameters were obtained from analysis of the TG-DTG curves by the Achar method, the Madhusudanan-Krishnan-Ninan (MKN) method, the Ozawa method and the Kissinger method. The most probable mechanism function was suggested by comparing the kinetic parameters. The kinetic equation for the first stage can be expressed as: dα/dt=Aexp(–E/RT)3(1–α)2/3.
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  • 134
    Digitale Medien
    Digitale Medien
    Springer
    Journal of thermal analysis and calorimetry 63 (2000), S. 397-413 
    ISSN: 1572-8943
    Schlagwort(e): Cu–5 at%Zn ; DSC ; F.C.C. (Face Centered Cubic) ; kinetics ; short-range-order ; solute-vacancy complexes
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract A modified first order kinetic law, which describes the roles of bound and unbound vacancies, is proposed in order to predict defect decay and short-range-order kinetics of quenched binary alloys during linear heating experiments. The model has been applied to differential scanning calorimetry (DSC) curves of Cu–5 at%Zn quenched from different temperatures. Activation energy for migration of solute-vacancy complexes was also assessed from the kinetics of short-range-order using DSC traces. A value of 89.5±0.32 kJ mol–1 was obtained. The relative contribution of bound and unbound vacancies to the ordering process as influenced by quenching temperature was determined. In conjunction, a parametric study of the initial total defect concentration and effective energy for defect migration was performed in order to envisage their influence on the calculated DSC profiles.
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  • 135
    Digitale Medien
    Digitale Medien
    Springer
    Journal of thermal analysis and calorimetry 60 (2000), S. 25-33 
    ISSN: 1572-8943
    Schlagwort(e): DSC ; kinetics ; thermal decomposition ; 2,4,6-trinitrotoluene
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract An autocatalytic model involving the limited solubility of volatile catalytic products was applied to the thermal decomposition of 2,4,6-trinitrotoluene. The critical supersaturation of the thermal decomposition products with the catalytic properties was higher at a low heating rate. Decrease of the sample mass led to an increased critical supersaturation of the decomposition products. This is probably a result of the greater contribution of products adsorption on the aluminium pan surface. It is presumed that the differences observed in the rate constant are connected with the uncontrolled critical supersaturation of the volatile thermal decomposition products.
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  • 136
    Digitale Medien
    Digitale Medien
    Springer
    Structural chemistry 11 (2000), S. 341-346 
    ISSN: 1572-9001
    Schlagwort(e): Positronium chemistry ; kinetics ; spin-exchange reactions ; high- and low-spin 3d complexes
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract Continuing in our work on the correlations between the rate constants, k CR, of the ortho into para-positronium conversion reactions, CR, promoted by complexes of various 3d ions and the metal electron delocalization β caused by the ligands, the relationship between the parameters of the correlation lines pertinent to highand low-spin complexes of CrII, MnII, and CoII ions was ascertained. Moreover, it was experimentally verified, for the first time, that the statistical probability of the CR promoted by paramagnetic compounds with S = 1/2 is three times larger than that of the CR caused by compounds with S 〉 1/2.
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  • 137
    Digitale Medien
    Digitale Medien
    Springer
    Hyperfine interactions 128 (2000), S. 481-493 
    ISSN: 1572-9540
    Schlagwort(e): muon catalyzed fusion ; triple mixture ; kinetics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract In this paper, we solve numerically kinetic equations for the chain reactions of μCF in triple H/D/T mixture. Regarding the computational results, we show that μCF efficiency decreases by adding hydrogen H to D/T mixture. This is in contradiction to the usual belief which expects the increase of μCF efficiency in H/D/T mixture. Our results are confirmed by the first and recent experiment on μdt cycling rate in the triple mixture.
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  • 138
    Digitale Medien
    Digitale Medien
    Springer
    Reaction kinetics and catalysis letters 69 (2000), S. 169-176 
    ISSN: 1588-2837
    Schlagwort(e): Al3+-exchanged pillared clay catalyst ; 2-methoxyethanol ; esterification ; kinetics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract The pillared clay catalyst, which was obtained by exposing activated clay powder to sulfuric acid and aluminium salts and calcining in air at 373 – 673 K, was found to be highly active for the title reaction. The activity is mainly attributed to the Lewis acid sites and also to a small number of Brönsted acid sites, whose number and strength increases with the extent of pillaring. The kinetic equation of surface esterification is y = 2.57x - 1.47.
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  • 139
    Digitale Medien
    Digitale Medien
    Springer
    Reaction kinetics and catalysis letters 70 (2000), S. 119-124 
    ISSN: 1588-2837
    Schlagwort(e): Tenoxicam ; photodegradation ; kinetics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract Photodegradation of tenoxicam was investigated under different reaction conditions. After 60 min of exposure to UV light, the photodegradation was extensive, and the maximum and minimum in the UV-visible spectrum were shifted to shorter and longer wavelengths, respectively. Ethanol exerted a photostabilizing effect on tenoxicam. Tenoxicam is more stable in acidic and basic media than in neutral solution. Increasing light intensity or temperature causes an increase in the rate of photodegradation. The photodegradation of tenoxicam was found to follow first-order kinetics under all these conditions.
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  • 140
    ISSN: 1588-2837
    Schlagwort(e): Ferrites ; aniline alkylation ; kinetics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract Kinetic parameters such as the activation energy (Ea) and Arrhenius frequency factor (A) for the N-methylation of aniline using methanol over Zn-Co ferrites have been calculated. The Ea value is found to be lower than the existing best alkylating systems such as γ-alumina and magnesium oxide.
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  • 141
    Digitale Medien
    Digitale Medien
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    Reaction kinetics and catalysis letters 71 (2000), S. 343-347 
    ISSN: 1588-2837
    Schlagwort(e): Deoximination ; chromium (VI) ; kinetics ; mechanism
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract Oxidative deoximination of aldoximes and ketoximes by pyridium fluorochromate proceeds by nucleophilic attack of the chromate oxygen on the oxime carbon to give a cyclic intermediate in the rate-determining step.
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  • 142
    Digitale Medien
    Digitale Medien
    Springer
    Reaction kinetics and catalysis letters 70 (2000), S. 147-151 
    ISSN: 1588-2837
    Schlagwort(e): Oxo-functionalization ; [RuIII(amp)(pic)(H2O)] ; t-BuOOH ; kinetics ; cyclohexane cyclohexene ; toluene
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract A novel mixed-ligand [RuIII(amp)(pic)(H2O)] complex (1) (H2amp = N-(hydroxyphenyl)salicyldimine; pic = picolinate) has been synthesized and characterized by physico-chemical methods. Complex 1has been found to be an effective catalyst in oxo-functionalization of C-H bond of organic substrates by using tert-butyl hydroperoxide (t-BuOOH) as a terminal oxidant. Formation of a high valent Ru(V)-oxo species as catalytic intermediate is proposed to be the source of oxygen atom in the oxidised product.
    Materialart: Digitale Medien
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  • 143
    ISSN: 1588-2837
    Schlagwort(e): Fe(CN)5(4-tbupy)3- ; kinetics ; electrolytes ; substitution
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract The ligand substitution reaction [Fe(CN)5(4-tbupy)]3- + pyrazine (4-tbupy=4-tertbutylpyridine) was studied in aqueous concentrated electrolyte solutions at 298 K. Plots of ln(k/kw) against (γ-γw), where the subscript w refers to pure water and γ is the surface tension of the appropriate salt solution, gave a common straight line for all the electrolytes studied and permits to estimate the activation volume.
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  • 144
    Digitale Medien
    Digitale Medien
    Springer
    Reaction kinetics and catalysis letters 69 (2000), S. 39-46 
    ISSN: 1588-2837
    Schlagwort(e): Coke formation ; kinetics ; USHY zeolites ; ethene ; propene ; 1-butene
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract A simplified three-parameter model for the interpretation of the kinetic data of coke formation during transformation of light olefins is presented. This model has been applied to the transformation of ethene, propene and 1-butene over fresh and regenerated zeolite USHY at 623 K. The proposed model covers both the coverage of the acid sites and the autocatalytic growth of coke.
    Materialart: Digitale Medien
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  • 145
    Digitale Medien
    Digitale Medien
    Springer
    Reaction kinetics and catalysis letters 69 (2000), S. 161-167 
    ISSN: 1588-2837
    Schlagwort(e): Dichlorocyclopropanation ; 4-vinyl-1-cyclohexene ; phase transfer catalysis ; kinetics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract The kinetics of regioselective dichlorocyclopropanation of 4-vinyl-1-cyclohexene has been studied under controlled phase transfer catalysis conditions, using aqueous sodium hydroxide as the base and 2-benzylidine-N,N,N,N′,N′,N′-hexaethylpropane-1,3-diammonium dibromide (Dq-Br) as a new phase transfer reagent. The reaction was carried out at 40 °C under pseudo-first order conditions by employing aqueous sodium hydroxide and chloroform in excess and was monitored by gas chromatography. The effect of various experimental parameters on the rate of the reaction has been studied and based on the experimental results, a suitable mechanism is proposed.
    Materialart: Digitale Medien
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  • 146
    Digitale Medien
    Digitale Medien
    Springer
    Reaction kinetics and catalysis letters 69 (2000), S. 247-252 
    ISSN: 1588-2837
    Schlagwort(e): Phosphorous acid ; oxidation ; kinetics ; mechanism
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract The oxidation of lower phosphorus oxyacids by benzyltrimethylammonium chlorobromate (BTMACB) proceeds by a mechanism involving a hydride-ion transfer from oxyacids to the oxidant in the rate-determining step.
    Materialart: Digitale Medien
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  • 147
    Digitale Medien
    Digitale Medien
    Springer
    Reaction kinetics and catalysis letters 70 (2000), S. 139-145 
    ISSN: 1588-2837
    Schlagwort(e): Oxidation of sulfides ; kinetics ; Ni-oxide system ; reaction mechanism
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract Catalytic oxidation of sulfide ions in aqueous solutions by air oxygen has been investigated using a Ni-oxide system as a catalyst. The kinetics and the selectivity of the oxidation process were studied by varying the pH, catalyst amount and reaction temperature. A reduction/oxidation mechanism of the reaction has been supposed comprising interaction between the surface active oxygen of the catalyst and HS− and reoxidizing of the reduced catalyst by the dissolved oxygen. The results obtained show that the Ni-oxide system is a promising catalyst for practical application.
    Materialart: Digitale Medien
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  • 148
    Digitale Medien
    Digitale Medien
    Springer
    Reaction kinetics and catalysis letters 70 (2000), S. 235-241 
    ISSN: 1588-2837
    Schlagwort(e): Methanol ; isobutanol ; ethers ; γ-Al2O3 ; kinetics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract The kinetic of methanol (MeOH) and isobutanol (iBuOH) coupling to ethers has been studied. Catalytic tests were carried out in the gas phase in a fixed-bed flow microreactor, in the temperature range of 463-533 K, under atmospheric pressure, using γ-Al2O3 as the catalyst. The quasi-homogeneous model for the process was assumed. The reaction rates were described by simple kinetics.
    Materialart: Digitale Medien
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  • 149
    Digitale Medien
    Digitale Medien
    Springer
    Reaction kinetics and catalysis letters 70 (2000), S. 319-324 
    ISSN: 1588-2837
    Schlagwort(e): Atmospheric chemistry ; kinetics ; OH-radical ; CH2F2
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract The rate constant value of k 1 = (6.05 ± 0.20)×109 cm3 mol−1 s−1 (with ± 1σ error) has been determined for the reaction OH + CH2F2 (1) by applying the discharge-flow/resonance-fluorescence method at 298 K.
    Materialart: Digitale Medien
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  • 150
    Digitale Medien
    Digitale Medien
    Springer
    Reaction kinetics and catalysis letters 71 (2000), S. 47-54 
    ISSN: 1588-2837
    Schlagwort(e): Alkylbenzenes ; hydrogenation ; nickel ; kinetics ; stereochemistry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract Experimental data on gas-phase hydrogenation of several alkylbenzenes (toluene, ethlylbenzene, o-, m-, p-xylenes, mesitylene) over nickel catalyst are summarized. Rate dependence as a function of the chemical nature of substituent and position in the aromatic ring is discussed. The stereochemical distribution for dialkylbenzene and trialkylbenzene is addressed.
    Materialart: Digitale Medien
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  • 151
    Digitale Medien
    Digitale Medien
    Springer
    Reaction kinetics and catalysis letters 71 (2000), S. 295-300 
    ISSN: 1588-2837
    Schlagwort(e): Sintering ; kinetics ; Pt/Al2O3
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract The variation of dispersion of Pt on Al2O3 support with sintering time is measured and the value of equilibrium dispersion of Pt is obtained directly. It is found that a General Power Law Expression can fit the experimental data well.
    Materialart: Digitale Medien
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  • 152
    Digitale Medien
    Digitale Medien
    Springer
    World journal of microbiology and biotechnology 16 (2000), S. 601-605 
    ISSN: 1573-0972
    Schlagwort(e): Growth phases identification ; kinetics ; Rhizopus oryzae ; solid-state fermentation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: Abstract A general equation correlating the variation rate of the fermenting medium weight (dry matter) and the cell biomass growth rate in solid-state fermentation tests is proposed with the main purpose of identifying the microbial growth phases.
    Materialart: Digitale Medien
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  • 153
    Digitale Medien
    Digitale Medien
    Springer
    Interface science 8 (2000), S. 111-121 
    ISSN: 1573-2746
    Schlagwort(e): 8-hydroxyquinaldine ; electropolymerization ; adsorption ; glassy carbon ; kinetics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Maschinenbau , Physik
    Notizen: Abstract The kinetics and thermodynamics of the electropolymerization of the chelating agent 8-hydroxyquinaldine on GCE's (Glassy Carbon Electrodes') surface from aqueous phosphate buffers are reported. Thermodynamic functions related to the adsorption of the monomer on the GCE's surfaces were determinated. No contribution from GCE surface's functional group to the electropolymerization reactions was reported. The effects of monomer concentration, pH, and temperature on the electrochemical growth of poly 8-hydroxyquinaldine were investigated. The results suggest that the propagation of the electropolymerization process takes place via a free radical chain reactions. Furthermore, the results indicate that the electrochemical growth of the polymeric films is dictated by pre-polymerization adsorption on the electrode surface.
    Materialart: Digitale Medien
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  • 154
    Digitale Medien
    Digitale Medien
    Springer
    Chemistry of heterocyclic compounds 36 (2000), S. 857-861 
    ISSN: 1573-8353
    Schlagwort(e): salts of 2,5-dimercapto-1,3,4-thiadiazole ; alkylation ; kinetics ; electronic absorption spectra
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract A kinetic investigation has been carried out, using electronic absorption spectra, of the alkylation with benzyl chloride of the dihydrazine, monohydrazine, and the disodium salts of 2,5-dimercapto-1,3,4-thiadiazole, and also of the hydrazine and sodium salts of 5-benzylthio-2-mercapto-1,3,4-thiadiazole. The rates orders and constants were established for the benzylation reaction and it was noted that the reaction rate depends on the cation of these salts and the degree of substitution of the 2,5-dimercapto-1,3,4-thiadiazole.
    Materialart: Digitale Medien
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