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  • 1985-1989  (1)
  • 1960-1964  (2)
  • 1880-1889
  • 1987  (1)
  • 1964  (2)
  • 1960
  • Hydrolysis
  • 1
    Electronic Resource
    Electronic Resource
    Kinetics of hydrolysis in vitro of nornitrogen mustard, a metabolite of phosphoramide mustard and cyclophosphamide (1987)
    Springer
    Archives of toxicology 61 (1987), S. 126-130 
    Details
    ISSN: 1432-0738
    Keywords: Nornitrogen mustard ; Phosphoramide mustard ; Hydrolysis ; Half-life ; Hydroxylation ; pKa
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A gas chromatographic (GC-ECD) method was developed for the determination of nornitrogen mustard (NOR) and its hydrolysis products. The method was based on derivatization by heptafluorobutyric anhydride. The structures of the derivatives of NOR were established by GC-MS. The method was used to characterize the rate of transformation of NOR and phosphoramide mustard (PAM), important metabolites of cyclophosphamide, into secondary products in vitro at 37° C and pH 7.4. The rate of disappearance of NOR had a half-life of 20 min. The half-life of appearance of N-(2-chloroethyl)-N-(2-hydroxy-ethyl)amine (NOR-OH) was 19 min. While most NOR appeared to be converted to NOR-OH, the yield of N,N-bis(2-hydroxyethyl)amine (NOR-OH-OH) was a small fraction of the starting material. The disappearance of NOR, when PAM was used as a starting material, had a half-life of 19 min; in these experiments NOR-OH and NOR-OH-OH were relatively much more abundant compared to when NOR was used as the starting material.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00661370
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The Reaction of Oxides with Water at High Pressures and TemperaturesDedicated to Prof. Dr. H. Brockmann on the occasion of his 60th birthday (1964)
    Weinheim : Wiley-Blackwell
    Angewandte Chemie International Edition in English 3 (1964), S. 47-54 
    Details
    ISSN: 0570-0833
    Keywords: Oxides ; Water ; High-pressure chemistry ; Hydrolysis ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The reactions of the oxides SiO2, MoO3, and WO3 with steam at temperatures between 400 and 700 °C and pressures of 5 to 500 atm were studied by means of the transfer method. The results were evaluated by a new method. In the system Sio2/H2O the formation of gaseous Si(OH)4, Si2O(OH)6, and [SiO2(OH)2]x was found to occur in three different water-density ranges. In the systems MoO3/H2O and WO3/H2O the gaseous compounds MoO2(OH)2 and WO2(OH)2, which were already known, exist up to densities of approximately 0.05g/cm3. At higher densities, at which the supercritical phase begins to show the properties of a liquid to an ever increasing extent, isopolymolybdic or isopolytungstic acids appear.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/anie.196400471
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Proton Transfer, Acid-Base Catalysis, and Enzymatic Hydrolysis. Part I: ELEMENTARY PROCESSESPart II (Catalytic Mechanisms) will appear shortly in this journal.Dedicated to Dr. W. Foerst on the occasion of his 65th birthday (1964)
    Weinheim : Wiley-Blackwell
    Angewandte Chemie International Edition in English 3 (1964), S. 1-19 
    Details
    ISSN: 0570-0833
    Keywords: Proton transfer ; Catalysis ; Enzyme catalysis ; Hydrolysis ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The proton occupies a special position as a promoter and mediator in chemical reactions occurring in solution. Many reactions in organic chemistry are catalysed by acids or bases; likewise, most enzymes contain active groups which promote acid-base catalysis. To understand the reaction mechanisms involved, it is necessary to identify the elementary steps as well as their course in time. Systematic investigation of these elementary steps as well as their course in time. Systematic investigation of these elementary steps has become possible only with the development of new methods for studying very fast reactions. The present paper reviews the information obtained in this type of investigation. The result is a relatively complete picture of the elementary proton transfer mechanisms and a comprehensive description of the modes and laws of acid-base and enzymatic catalysis.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/anie.196400011
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    Paper (German National Licenses)
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