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  • 1
    Electronic Resource
    Electronic Resource
    Drug-related test patterns of depressed patients (1976)
    Springer
    Psychopharmacology 50 (1976), S. 205-210 
    Details
    ISSN: 1432-2072
    Keywords: Depression ; Imipramine ; Chlorpromazine ; Psychological tests ; Psychopharmacology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Several types of drugs reportedly have been useful in treating depressions, but the specific effects of these drugs on functioning remain unclear. Fortynine hospitalized depressed patients were randomly assigned on a double-blind basis to an imipramine, chlorpromazine or placebo group. Psychological test performance was compared after 3 weeks of in-hospital drug treatment. Neither drug produced impairment on most measures of intellectual functioning. The results suggest imipramine may impair ability to assimilate and retain information, and that chlorpromazine may impair sustained attention. The differential effects were discussed in relation to symptoms, and to hypotheses about the relationship between arousal and chlorpromazine and between retardation and imipramine in the treatment of depression.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00430494
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Sensory, perceptual, motor and cognitive functioning and subjective reports following oral administration ofΔ 9-Tetrahydrocannabinol (1976)
    Springer
    Psychopharmacology 47 (1976), S. 141-148 
    Details
    ISSN: 1432-2072
    Keywords: Δ 9-tetrahydrocannabinol (THC) ; Psychometrics ; Psychopharmacology ; Subjective drug effects questionnaire
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Three dose levels, 0.2, 0.4 and 0.6 mg/kg, ofΔ 9-tetrahydrocannabinol (THC) and a placebo were orally administered to 10 frequent and 10 occasional marijuana users. Following ingestion of each dose and the placebo, objective tests selected from a battery of sensory and perceptual motor tests routinely used to evaluate cerebral dysfunction in hospitalized patients were administered. The influence ofΔ 9-THC on proficiency and variability of performance was minimal. However, when individual test scores and variabilities were combined and converted to standard scores, allowing for analysis of overall performance, THC had a small but consistent detrimental effect on both proficiency and variability of performance. In contrast, THC exerted profound effects on the subjective experiences of the volunteers as assessed by the Subjective Drug Effects Questionnaire. Subjective changes in mood, feeling, perception and somatic sensations were reported by all subjects but were more pronounced in the occasional user group. It was proposed that the small impairment noted in objective test performance after ingestion ofΔ 9-THC as contrasted to the large effects on subjective responses suggests that the principal effects of marijuana are on the autonomic nervous system rather than on higher cortical functions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00735812
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Benzylidenaminooxy-CarbonsÄure-Derivate als Auslöser von „Wet Dog Shake“-Verhalten bei normalen Ratten (1976)
    Springer
    Psychopharmacology 46 (1976), S. 191-196 
    Details
    ISSN: 1432-2072
    Keywords: Chemically induced wet shake behavior ; Rats ; Benzylideneaminooxycarbonic acids ; Sgd 8473 ; Drug dependence ; Psychopharmacology ; Quasi-abstinence ; Methods
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Wet dog shake (WDS) behavior in rats, well known as morphine-withdrawal syndrome, could be elicited without concomitant symptoms for the first time chemically in nonmorphine-addicted animals. The capability to produce WDS was correlated with a specific chemical structure among the title-compounds. The threshold-dose of the most effective agents was 25–50 mg/kg, rather independent of the mode of application. Maximal responses of 10–20 WDS per min and animal were reached after application of 100–200 mg/kg. WDS behavior appeared within the first minutes after dose and lasted up to several hours. Detailed information is given on WDS-action of the substance Sgd 8473=α-[(4-chlorobenzylideneamino)-oxy]-isobutyric acid and the influence by different pharmacologic agents thereon. Inhibition of WDS was produced by: narcotic analgesics, narcotic antagonists, psychosedativ drugs, yohimbine, dl-amphetamine, cocaine, apomorphine and clonidine. Without influence on WDS were: physostigmine, atropine, ganglionic- or adrenergic-blocking drugs, Dopa, MAO-inhibitors, serotonin- and histamin-antagonists and nonnarcotic analgesics. To some extent chemically induced WDS seemed to be susceptible like precipitated WDS. So Sgd 8473 could be qualified for differentiating narcotic and nonnarcotic analgesics, for a “quasi-abstinence” agent in research of dependence mechanisms and for a tool in neuroanatomical studies of the CNS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00421391
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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