ISSN:
0570-0833
Keywords:
Stereoselectivity
;
Reaction mechanisms
;
Synthetic methods
;
Free radicals
;
Chemistry
;
General Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The regio- and chemoselectivities of free radical reactions are often high and largely predictable; systematic studies have now shown that the stereoselectivity of free radical reactions can also be directed. Examples involving five- and six-membered cyclic radicals will be used to show how steric and stereoelectronic effects influence the diastereoselectivity of reactions of cyclic radicals with olefins. The temperature, the solvent, and the nature of the radical scavenger used also play a role, so that, if the correct reaction conditions are used, the stereoselectivity of reactions for cyclic reactants can be very high. Lower stereoselectivities are often observed for reactions between acyclic radicals and acyclic alkenes. However, preliminary experiments have indicated that under certain conditions such systems can also react in a stereoselective manner.
Additional Material:
9 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/anie.198909693
Permalink
